摘要
目的:通过观察深静脉血栓形成(DVT)患者凝血、抗凝和纤溶系统各项指标的变化,探讨高凝状态在DVT发病机制中的重要作用,指导临床采用合理的预防及治疗措施。方法:以60例健康查体者作为对照组,测定60例DVT患者的血小板数量(BPC)、血小板聚集率(PAgT)、血小板α颗粒膜蛋白(GMP-140)含量;血浆凝血酶原时间(PT)、凝血酶时间(TT)、部分凝血活酶时间(ATPP)、纤维蛋白原(Fg)、血管性血友病因子(vWF)含量;抗凝血酶Ⅲ(AT-Ⅲ)、蛋白C(PC)活性、蛋白S(PS)含量;纤溶酶原(PIg)、组织型纤溶酶原激活物活性(tPA)及纤溶酶原激活物抑制物-1(PAI-1)活性。结果:与正常对照组相比,DVT患者PAgT、GMP-140、Fg、vWF含量及PAI-1活性明显升高:PT、TT、APTT、AT-Ⅲ、PC、PS、PIg及tPA活性水平均明显降低(均P<0.01)。结论:血液凝血、抗凝和纤溶活性异常所致的高凝状态在DVT发病机制中占有重要地位,临床应采用凝血、抗凝和纤溶联合指标指导DVT的防治,以取得最佳效果。
Objective：Coagulant,anticoagulant and fibrinolytic function of patients with deep venous thrombosis,were assayed.To detemine the important role of hypercoagulation in development of this disease.Methods：60 DVT patients and 60 normal controls were studied. All patients were evaluated respectively by examining their blood BPC, PagT, GMP- 140, PT,TT, APTT, Fg, VWF, AT- Ⅲ, PC, PS,PIg,tPA-A and PAI-1, Result： The level of PagT,GMP-140,Fg,VWF 及 PAI-1,in DVT group are higher than normal control group. The level of PT, TT, APTT, AT- Ⅲ, PC, PS, Pig and tPA in DVT group are significantly lowe, than in normal control group（all P〈0.01）.Conclusion：Hypercoagulation is the most important factor in development of DVT patients. The level of coagulant,anticoagulant and fibrinolytic function can be adopted to assay the clinical therapy effect.
出处
《中国交通医学杂志》
2006年第2期184-185,187,共3页
Chinese Medical JOurnal of Communications
关键词
深静脉血栓
凝血系统
抗凝系统
纤溶系统
Deep venous thrombosis
Coagulant
Anticoagulant
Fihrinolytic function
