摘要
目的 观察腺苷蛋氨酸（SAMe）治疗新生儿黄疸的疗效，探讨其作用机制。方法新生儿黄疸患儿278例，随机分为两组。对照组76例予以肝酶诱导剂、光疗等综合治疗；治疗组202例在综合治疗基础上加用SAMe 30～60mg／（kg·d）。静脉注射。动态检测血清总胆红素（T—BILl）、直接胆红素（D-BILI）、间接胆红素（I-BILI）。结果治疗组用药6d后血清T-BILl、D—BILl、I-BILI明显下降。治疗组较对照组治愈率明显高，与对照比较应用血液制品、清蛋白（Alb）次数及应用血液制品、Alb血浆的比例11月显减少。治疗组以葡萄糖注射液溶解药物者2．68％发生浅表血管静脉炎。结论SAMe能有效地加快新生儿黄疸的消退，减少血液制品应用，是新生儿黄疸可靠、安争的治疗药物。
Objective To observe the effect of S-adenosyl-L-methionine（SAMe） in treatment of jaundice in newborns and its mechanism. Methods Two hundred and two newborn infants with jaundice were treated with SAMe, 76 eascs in control group treated with phototherapy and liver enzyme induction elixir; SAMe 30 - 60 mg/（ kg·d） were added to 202 cases intravenously in treatment group, The total biliorubin（T-BILI）,direct bilinrubin（D-BILl） and indirect bilinrubin（I-BILl） were dynamically detected. Results Six days after treatment, the skin jaundice index in treatment group decreased remarkably. T - BILl, D - BILl and I - BILl decreased significantly. The curing effectiveness was higher in treatment group than that in control group. The number of applieating blood products and albumin, and blood products/albumin were decreased in treatment group than those in control group. In those who used glucose to dissolve the SAMe 2.68% had blood- vessel phlebitis. Conclusions SAMe can efficiently quicken the retrogression of jaundice in newborns. It can reduce the use of blood products. It is a reliable and safe drug to treat jaundice in newborns.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第8期498-499,共2页
Journal of Applied Clinical Pediatrics
关键词
婴儿
新生
黄疸
腺苷甲硫氨酸
newborn infant
jaundice
S- adenosyl- L- methionine
