摘要
大鼠一次腹腔注射ＡＭＺ后，血中毒物浓度的动力学变化呈二室开放模式。动力学参数为：Ｋａ１．２７５７ｈ－１，Ｔ１／２α２．８１６ｈ，Ｔ１／２β８２．２１ｈ，Ｔ１／２Ｋａ０．５４３２ｈ，Ｔｍａｘ１．９７３ｈ，Ｋ１２０．１６１５ｈ－１，Ｋ２１０．０７３２ｈ－１。结果显示，ＡＭＺ能迅速吸收和分布到组织中。在肝、脑组织中，ＡＭＺ浓度的时程变化也呈二室开放模式，且从脑组织中消除速度很慢。体外实验ＡＭＺ能明显抑制脑组织ＡＣ活性，呈剂量效应关系。体内实验则显示对大脑ＡＣ活性的持续性抑制。
In this paper,the toxicokinetic characteristic of Amitraz and the effect to AC activity of cerebral tissue of rats was studied both in vitro and in vivo.The restult showed remarkable inhibition of the cerebral AC activity with administration AMZ and singnificant correlation of dose effect( r=-0 9970,P <0 01).The time curve of blood AMZ concentration was fitted to a two compartment open model after a single ip administration (75mg/kg) in rats.The toxicokinetic paratmeters were as following:Ka 1 2757h -1 ,T 1/2Ka 0 5432h,T 1/2α 2 816h,T 1/2β 82 21h,K 12 0 1615h -1 ,K 21 0 0732h -1 ,T max 1 973h.This result indicated that the absorption and distribution of AMZ in rats was rapid.The time curves of AMZ concentration in cerebral and hepatic tissues also revealed same models,but the elimination of AMZ in cerebral tissue was very slow.
出处
《现代预防医学》
CAS
1996年第2期97-99,共3页
Modern Preventive Medicine
基金
国家自然科学基金
CMB基金
