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乳腺癌特异性基因1的生物学特性及与恶性肿瘤的关系 被引量：1

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摘要 乳腺癌特异性基因1(BCSG1)与突触核蛋白家族有很高的同源性,被视为该家族的第3个成员,因此该基因又被称为γ突触核蛋白(SNCG)。近年来研究发现BCSG1与乳腺癌和卵巢癌密切相关,在多数进展期乳腺癌和卵巢癌中特异性高表达,因此在乳腺癌的预后判断及抗肿瘤药物筛选中有重要作用。该文综述了该基因的结构、表达特性、信号转导及影响表达的相关作用因子,并对该基因在神经系统疾病及在乳腺癌和卵巢癌中的表达作了简要的概述,另外还对该基因的应用前景作了展望。
作者 何帮顺 王书奎
机构地区 南京医科大学附属南京第一医院中心实验室
出处 《国际检验医学杂志》 CAS 2006年第4期332-334,共3页 International Journal of Laboratory Medicine
关键词 乳腺肿瘤 基因 突触蛋白类 卵巢肿瘤
分类号 R737.9 [医药卫生—肿瘤] R737.31 [医药卫生—肿瘤]
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参考文献15

  • 1Ji H,Liu YE,Jia T,et al.Identification of a breast cancer-specific gene,BCSG1,by direct differential cDNA sequencing.Cancer Res,1997,57(4):759-764.
  • 2Lavedan C,Leroy E,Dehejia A,et al.Identification,localization and characterization of the human gamma-synuclein gene.Hum Genet,1998,103(1):106-112.
  • 3Ninkina NN,Alimova-Kost MV,Paterson JW,et al.Organization,expression and polymorphism of the human persyn gene.Hum Mol Genet,1998,7(9):1417-1424.
  • 4Lu A,Gupta A,Li C,et al.Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells:control of transcription by DNA methylation and intronic sequences.Oncogene,2001,20(37):5173-5185.
  • 5Gupta A,Godwin AK,Vanderveer L,et al.Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma.Cancer Res,2003,63(3):664-673.
  • 6Bruening W,Giasson BI,Klein-Szanto AJ,et al.Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary.Cancer,2000,88(9):2154-2163.
  • 7Lu A,Zhang F,Gupta A,et al.Blockade of AP1 transactivation abrogates the abnormal expression of breast cancer-specific gene 1 in breast cancer cells.J Biol Chem,2002,277(35):31364-31372.
  • 8Liu J,Spence MJ,Zhang YL,et al.Transcriptional suppression of synuclein gamma (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M.Breast Cancer Res Treat,2000,62(2):99-107.
  • 9Gupta A,Inaba S,Wong OK,et al.Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1.Oncogene,2003,22(48):7593-7599.
  • 10Jiang Y,Liu YE,Goldberg ID,et al.Gamma synuclein,a novel heat-shock protein-associated chaperone,stimulates ligand-dependent estrogen receptor alpha signaling and mammary tumorigenesis.Cancer Res,2004,64(13):4539-4546.

二级参考文献6

  • 1Bruening W, Giasson BI, Klein-Szanto AJ, et al. Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer,2000,88:2154-2163.
  • 2Ninkina NN, Alimova-Kost MV, Paterson JW, et al. Organization, expression and polymorphism of the human persyn gene.Hum Mol Genet,1998,7:1417-1424.
  • 3Horita K, Yamaguchi A, Hirose K, et al. Prognostic factors affecting disease-free survival rate following surgical resection of primary breast cancer. Eur J Histochem, 2001,45: 73-84.
  • 4Menard S, Fortis S, Castiglioni F, et al. HER2 as a prognostic factor in breast cancer. Oncology, 2001,61(supp1 2) :67-72.
  • 5Velculescu VE, Zhang L, Vogelstein B, et al. Serial analysis of gene expression. Science, 1995,270:484-487.
  • 6Jia T, Liu YE, Liu J, et al. Stimulation of breast cancer invasion and metastasis by synuclein γ. Cancer Res, 1999,59:742-747.

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国际检验医学杂志
2006年 第4期

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