摘要
基质金属蛋白酶(MMP)和金属蛋白酶组织抑制因子(TIMP)是细胞外基质(ECM)合成和降解调节中的两个重要的因素。其中MMP-1主要降解细胞外基质的主要成分Ⅰ、Ⅲ型胶原,TIMP-1可抑制MMP-1的活性。肝纤维化时MMP-1活性下降,而TIMP-1活性不断升高。研究显示,二者活性失衡是导致肝纤维化进展的重要因素。它们的来源结构、活性的调节及功能成为目前的研究热点。
Matrix metalloproteinase （MMP） and tissue inhibitor of metalloproteinase （TIMP） are the two important factors about regulation of synthesis and degradation of extracellular matrix （ECM）. MMP 1 degradates type Ⅰ and type Ⅲ collagen which are principal constituent of ECM. TIMP-1 may suppress activity of MMP-1 and promote the progress of hepatic fibrosis. In hepatic fibrosis activity of MMP 1 decreases, but activity of TIMP-1 increases. The researches demonstrate that, the unbalance of activity of both is the important factor about hepatic fibrosis progress. Their origin , structure, regulation and function become the hotspot of research.
出处
《国际消化病杂志》
CAS
2006年第2期109-112,共4页
International Journal of Digestive Diseases
基金
兵团科技攻关计划课题(04GG22)
