摘要
目的通过新辅助化疗提高局部乳腺癌的手术切除率的近期和远期疗效并比较两种不同方案新辅助化疗的疗效。方法106例局部晚期乳腺癌患者分为两组,A组采取CMF方案,B组采取CTF方案进行新辅助化疗,观察肿瘤、腋窝淋巴结的变化,为手术切除提供较好的条件。结果新辅助化疗总有效率为64.2%,其中A组有效率为50.0%,B组为78.9%。A、B两组5年生存率和无病生存率(DFS)分别为37.1%、65.5%和25.9%、55.8%。结论新辅助化疗方案对局部晚期乳腺癌的原发肿瘤及腋窝淋巴结转移灶均有效,为根治性手术和保乳手术创造了条件,提高了生存率和无病生存率,CTF方案效果优于CMF方案。
Objective To improve the short-term and long-term efficacy of operative excision of local breast cancer through new adjuvant chemotherapy and to compare the curative effects of two different regimens of new adjuvant chemotherapy. Methods 106 cases of local advanced breast cancer were divided into 2 groups. Group A adopted CMF and group B adopted CTF as new adjuvant chemotherapy. The changes of tumour and axillary lymph node were observed in order to provide a preferable condition for the operation excision. Results The overall response rate of new adjuvant chemotherapy was 64.2% ,with the response rate of CMF group being 50.0% and CTF group 78.9%. The five-year survival rate and DFS of group A and group B were 37.1% ,65.5% and 25.9% ,55.8% respectively. Conclusions The new adjuvant chemotherapy regimens were equally effective in treatment of the primary tumour of local advanced breast cancer and axillary lymph node, creating conditions for radical operation and breast-saving operation and improving the survival rate and DFS. The CTF regimen is superior to CMF regimen.
出处
《中国肿瘤临床与康复》
2006年第2期180-181,191,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
