摘要
目的对增生性瘢痕中神经肽P物质神经纤维与肥大细胞进行形态学观察,探讨增生性瘢痕中二者的相互作用情况。方法对神经肽P物质神经纤维及肥大细胞分别行免疫组化及甲苯胺蓝染色,进行形态学观察。结果在增生性瘢痕中,神经肽P物质神经纤维分支多且交错连接,正常皮肤中多为单根走形;瘢痕中肥大细胞数(7.22)显著多于正常皮肤(4.64),有统计学意义;增生性瘢痕中神经肽P物质与肥大细胞密切关联,呈“串珠”样形态。结论增生性瘢痕中神经肽P物质神经纤维与肥大细胞的密切关联,可能与瘢痕的增生和瘙痒相关。
Objective To observe the morphology of substance P nerve fiber and mast cells in hypertrophic scar and normal skin and investigate the interaction of substance P nerve fiber and mast cells in hypertrophic scar. Methods The hypertropic scar tissue and the normal skin was from 8 burnt patients who underwent operation owing to cicatricial contracture. The amount and shape of substance P nerve fiber and mast cells in hypertrophic scar were observed after immunohistochemistry and toluidine blue. Results In hypertropic scar tissue, the substance P nerve fiber was ramous and interlacing, but in normal skin, it was paralleled. The mast cells in the hypertropic scar tissue （7.22） were more than that in normal skin （4.64）. Substance P and mast cells showed close relationship in hypertrophic scar, as pearls＇ ap skin. Conclusion Substance P and mast cells have close substance P and mast cells may play an important role in the pearance that was more significant than in normal relationship in hypertrophic scar, indicating that development and pruritus of hypertrophic scar.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2006年第9期979-981,共3页
Journal of Third Military Medical University
