摘要
目的了解复治肺结核患者的细菌学及耐药情况和临床特征。方法分析69例临床分离株的耐药情况。应用聚合酶链反应-单链构象多态性(PCR-SSCP)和聚合酶链反应-限制性片段长度多态性(PCR-RFLP)进行了菌种鉴定。结果结果表明,利福平(REP)、异烟肼(INH)链霉素(SM)、吡嗪酰胺(PZA)和乙胺丁醇(EMB)耐药率分别为79.7%,68.1%,76.8%,69.5%和44.9%。非结核分支杆菌4株,为堪萨斯分支杆菌2株,鸟胞内分支杆菌1株,偶然脓肿分枝杆菌1株。3例治愈,1例死亡。结论复治肺结核病人中有一小部分为非结核分支杆菌肺病患者,菌型鉴定非常重要,有助于诊断和治疗。
Objective： To investigate the baetefiological and clinical feature of retreatment pulmonary tuberculosis. Methods： clinical isolated resistance drug strains from sputum specimens of 69 petients were analyzed. Bacterial type identify were peffomed by PCR - SSCP and PCR - RFLP. Results： The drug resistance rate of RFP, INH, SM, PZA and EMB of clinical isolated strains were 79.7 %, 68. 1%, 76.8 %, 69.5 % and 44.9% respectively. There were four strains of Nontuberculous myeohacterial in isolated strains, （two M. Kansasii Hauduroy, one M, avium complex and one M. fortuitum）, Three patients were recovered, one cried. Conclusion： There were small parl of petients with nontubereulous myeobaeterial disease in all ＂retreatment pldmonary tuberculosis＂ patients, bacterial type identify was very important. It may useful for diagnosis and treatment.
出处
《华西医学》
CAS
2006年第2期248-249,共2页
West China Medical Journal
