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绿茶多酚对D-半乳糖与Aβ25~35诱导的AD模型小鼠学习记忆障碍的改善作用 被引量:15

Effects of Green Tea Polyphenol on the Behaviour of Alzheimer's Disease Like Mice Induced by D-galactose and Aβ_(25~35)
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摘要 目的:建立D-半乳糖与Aβ25~35诱导的AD模型小鼠,观察绿茶多酚对其学习记忆障碍的改善作用.方法:皮下注射D-半乳糖(120 mg/kg,连续给药12 w),并在第7 w时于侧脑室注射Aβ25~35(4 nmol/L),建立AD模型小鼠.利用跳台法、水迷宫、避暗法和开场实验评价绿茶多酚对AD模型小鼠学习记忆障碍的改善作用.结果:绿茶多酚明显延长跳台潜伏期,减少跳台错误次数;缩短游出迷宫时间和减少进入盲端的错误次数;减少避暗活动错误次数和延长进入穿梭箱潜伏期;同时,明显增加AD小鼠的探究行为.结论:绿茶多酚对D-半乳糖与Aβ25~35诱导的AD模型小鼠学习记忆障碍具有改善作用. Objective: To study the effects of green tea polyphenol (GTP) on the behaviour of Alzheimer' s Disease like mice induced by D-galactose and Aβ25-35, Methods: D-galactose (120 mg/kg) was intraperitoneally injected into mice for 12 weeks and Aβ25-35 (4nmol) was injected by icv to establish Alzheimer' s Disease like mice. The protective and therapeutic effects of GTP were determined by using water maze test, step down test, step through test and open field test, Results: GTP ameliorated the deleterious effects of D-galaetose and Aβ25-35, and thereby improved the animal' s learning and memory, prolonged latency time, and the error numbers were significantly reduced. At the same time the autonomic activities were significantly increased. Conclusion: GTP can improve the behaviour of Alzheimer' s Disease like mice induced by D-galactose and Aβ25-35.
出处 《中药材》 CAS CSCD 北大核心 2006年第4期352-354,共3页 Journal of Chinese Medicinal Materials
基金 广东省医学科学研究课题(A2003363)
关键词 绿茶多酚 D-半乳糖 AΒ25~35 学习记忆 Green Tea Polyphenol D-galactose β-amyloid protein Learning behaviours
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