摘要
CD4+CD25+调节性T细胞是一类具有特殊免疫调节功能的T细胞亚群。它能够抑制自身免疫病的发生,参与肿瘤免疫的调节,在感染和移植免疫中也发挥着重要作用。T细胞的这一亚群具有免疫无能和免疫抑制特性,新近发现它亦与艾滋病的发生、发展关系密切。文中就CD4+CD25+调节性T细胞与HIV感染的研究进展进行综述。
CD4^＋ CD25^＋ regulatory T cells is a subset of regulatory T cells with special functions of regulation. These cells can prevent autoimmune diseases, regulate the antitumor immunity and play a crucial role in suppressing immune responses to inflammation and transplantation. This subset is hyporesponsive and anergic to antigen stimulation. Most recently, it was demonstrated that they participated in the immune deficiency in human immunodeficiency virus （HIV） infection. Here we review the current knowledge and functions of CD4^＋ CD25^＋ T cells in HIV infection.
出处
《国际流行病学传染病学杂志》
CAS
2006年第2期83-85,99,共4页
International Journal of Epidemiology and Infectious Disease
基金
国家自然科学基金(30471588)
