摘要
目的 探讨严重肝病并棘刺红细胞症的临床特点。方法 对2001年1月至2005年5月间桂林医学院附属医院儿科收治的7例严重肝病并棘刺红细胞症患儿的症状、体征，血细胞光镜检查，肝功能，血脂检查，预后，并结合文献资料进行总结分析。结果 7例中男4例，女3例，年龄5个月至9岁，主要临床表现有黄痘（6例）、出血（3例）、贫血（7例）、肝肿大（6例）或肝硬化（1例）、脾肿大（3例），外周血中棘刺红细胞占所有红细胞的8．5％-94．4％，肝功能损害明显，血脂均有不同程度的改变。结论 严重肝病并棘刺红细胞症临床罕见，这7例患儿的共同特点是：（1）原发病各异；（2）病程长；（3）有程度不等的贫血，红细胞平均容积（MCV）以增大为主；（4）外周血中均有多少不等的棘刺红细胞；（5）肝功能损害明显；（6）血脂均有多项改变；（7）预后不良。
Objective To explore the clinical characteristics of severe liver disease combined with spur cell anemia in 7 children. Methods The clinical data of 7 patients with such disease admitted to the pediatric ward in our hospital between January 2001 to March 2005 were analyzed. The data included symptoms, signs, laboratory examinations （ blood smear, liver function test and serum cholesterol ） and the literatures, etc. Results Seven patients consisted of 4 males and 3 females and the age ranged from 5 months to 9 years. The children manifested as jaundice（6 cases）, hemorrhage （3 cases ） ,anemia（7 cases ） ,large liver（6 cases ） or cirrhosis （ 1 case ） and megalospleen（ 3 Cases ）. Blood smear showed that spur cell was 8. 5% - 94. 38% of the whole erythrocytes in peripheral blood. Liver functions were destroyed badly. Serum cholesterols were abnormal. Conclusion The clinical characteristics of the children are summed up as：although the original disease might be different.the children are all characterized as long course,moderate to mild anemia,spur cell in peripheral blood,destroyed liver function,abnormal plasma cholesterol and bad prognosis.
出处
《中国实用儿科杂志》
CSCD
北大核心
2006年第5期376-379,共4页
Chinese Journal of Practical Pediatrics
关键词
严重肝病
棘刺红细胞
Severe liver disease
Spur cell
