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抑制消减杂交法筛选无症状乙型肝炎病毒携带者差异表达基因 被引量：2

Screening differentially expressed genes of asymptomatic HBV carriers by suppression subtracted hybridization
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摘要 乙型肝炎病毒（HBV）携带者中,大多数是婴幼儿期感染,往往终生携带HBV,但正常成人初次感染后大多能清除病毒.除病毒因素外,主要是机体的免疫因素决定感染结局[1].机体对HBV的免疫应答受许多基因的调节,我们推测正是由于在正常人和HBV携带者之间存在的免疫相关基因表达的差异才导致了不同的感染结局.本研究旨在探讨HBV携带者与正常人外周血单个核细胞（PBMC）差异表达的基因,有助于阐明HBV携带发生发展机制及设计新的治疗靶标.
作者 唐翠兰 陈智 羊正纲 周林福 陈峰 彭国平
机构地区 浙江大学附属第一医院传染病研究所
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2006年第4期302-303,共2页 Chinese Journal of Hepatology
基金 浙江省科技厅重大项目(2003C13015)
关键词 肝炎病毒 乙型 携带者 肝炎病毒 抑制消减杂交术 基因 Hepatitis B virus .Carrier,hepatitis B virus,Suppression subtracted hybridization Gene
分类号 R512.62 [医药卫生—内科学] R735.7 [医药卫生—肿瘤]
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中华肝脏病杂志
2006年 第4期

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