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用途可调节的生物磁性粒子的制备

Preparation of magnetic particles used at different biomedical fields
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摘要 采用部分还原沉淀法合成Fe3O4磁性粒子,通过热处理制度控制粒径和晶相的不同,得到磁性能表现不同的Fe3O4磁性粒子。利用透射电镜、原子力显微镜、激光粒度分析仪、X射线衍射仪、振动磁强计等对样品的粒度分布、晶相和磁性能进行表征。结果表明,不同热处理温度均可制备出粒度分布均匀的单分散的磁性粒子,且表现出较好的磁响应性、超顺磁性或者具有一定的磁滞和发热量,可以应用于生物分离、靶向药物载体或肿瘤热疗等不同的生物医学领域。 Fe3O4 particles were synthesized by partial reduction chemical precipitation method. The diameter of the particles and its crystal phase, which would have the effect on the magnetic property of the particles, were controlled by different heat treatment. Transmission electron microscope (TEM), atomic force microscope (AFM), laser particles size analyzer, X-ray diffractometer (XRD) and vibrating samples magnetometer (VSM) were used to characterize the size distribution, crystal phase and magnetic property of the particles. The results show that the monodisperse magnetic particles, which exhibit good magnetic response, superparamagnetism or the proper hysteresis, can be prepared by partial reduction chemical precipitation method and proper heat treatment. The particles could be used in bioseparation, targeted drug carrier or the tumor hyperthermia therapy.
出处 《材料热处理学报》 EI CAS CSCD 北大核心 2006年第2期1-5,共5页 Transactions of Materials and Heat Treatment
基金 国家自然科学基金项目(50272041) 上海市纳米专项赞助(0452nm059)
关键词 Fe3O4磁性粒子 热处理 晶相 粒径分布 磁性能 Biomedical engineering Biomedical equipment Heat treatment Iron oxides Magnetism Particles (particulate matter) Superparamagnetism
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