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核心蛋白多糖在病理性瘢痕形成中的作用

The Effect of Decorin In the Formation of Pathological Scarring
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摘要 核心蛋白多糖(decorin)是蛋白多糖家族中的一员。其生物活性十分活跃,它能中和、灭活转化生长因子-β(TGF-β)等多种细胞因子,具有调节基质重构、抗凋亡、抗炎及抗黏附等作用,是一种抗纤维化的蛋白质。本文主要对其生物学效应、调控方式及在病理性瘢痕中的作用作一综述。 Deeorin is a member of proteoglycans families, whose biologic effect is very active. Decorin can neutralize and inactivate many eytokine, such as TGF-β, which is a kind of anti-fibrosis protein playing its role in the regulation of extracellular matrix, anti-apoptosis ,anti-inflammation and anti-adherence. This article reviews decorin about its biologic effect, regulation method and its role in pathological scarring.
作者 孙家平 刘流
机构地区 昆明医学院第一附属医院口腔颌面外科
出处 《医学综述》 2006年第10期584-586,共3页 Medical Recapitulate
基金 云南省自然科学基金资助项目(2005C0072M)
关键词 核心蛋白多糖 病理性瘢痕 转化生长因子-Β Decorin Pathological -scar Insulin-like growth factor
分类号 R782.2 [医药卫生—口腔医学]
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参考文献15

  • 1Scott PG, McEwan PA, Dodd CM, et al. Crystal structure, of the dimeric protein core of Decorin, the archetypal small leucine-rich repeat proteoglycan [ J]. Proc Natl Acad Sci USA,2004,101 (44) : 15633-15638.
  • 2Carrino DA, Onnerfjord P, Sandy JD, et al. Age-related changes in the proteoglyeans of human skin. Specific cleavage of Decorin to yield a major catabolic fragment in adult skin [ J]. J Biol Chem, 2003,278(19) : 17566-17572.
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二级参考文献10

  • 1Kresse H, Schonherr E. Proteoglycans of the extracellular matrix and growth control. J Cell Physiol, 2001, 189:266-274.
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  • 4Stewart JE, Wheatley DN, Holmes JD, et al. Purification and identification of a human dermal extract component inhibitory to fibroblast proliferation. Cell Biol Int, 2001, 25:607-612.
  • 5Santra M, Mann DM, Mercer EW, et al. Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. J Clin Invest
  • 6Stander M, Naumann U, Wick W, et al. Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. Cell Tissue Res, 1999, 296:221-227.
  • 7Xaus J, Comalada M, Cardo M, et al. Decorin inhibits macrophage colony-stimulating factor proliferation of macrophages and enhances cell survival through induction of p27(Kip1) and p21(Waf1). Blood, 2001, 98:2124-33.
  • 8Yamaguchi Y, Mann DM, Ruoslahti E. Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature, 1990, 346:281-284.
  • 9Yeo TK, Brown L, Dvorak HF. Alterations in proteoglycan synthesis common to healing wounds and tumors. Am J Pathol, 1991, 138:1437-1450.
  • 10胡大海,陈璧,曹茂开,朱雄翔,徐明达.重组融合饰胶蛋白拮抗转化生长因子β_1刺激增生性瘢痕成纤维细胞增殖的作用[J].中华创伤杂志,2001,17(6):330-333. 被引量：9

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医学综述
2006年 第10期

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