摘要
肠球菌是多重耐药的重要条件致病菌和医院感染常见病原菌。氟喹诺酮类抗菌药是一类广谱抗菌药,其作用靶位是细菌的Ⅱ型拓扑异构酶,包括DNA旋转酶和拓扑异构酶Ⅳ。随着氟喹诺酮类抗菌药在临床广泛应用,肠球菌对其耐药性迅速增长。肠球菌对氟喹诺酮类抗菌药的耐药机制主要为靶位改变和药物主动外排导致的细胞内药物积聚减少。
Enterococci are known as the most important multi drug resistant opportunistic pathogens and common cause of bospital-acqnired infections. Fluoroquinolones （FQs）are broad-spectrum antibacterial agents, the targets of which are type Ⅱ topoisomerases including DNA gyrase and topoisomerase Ⅳ, Increasing resistance to FQs in enterecoci has been noted with these agents broadly used in clinical medicine. The main two mechanisms of FQs resistance in entereeocci are alterations in the targets of FQs and decreased intra-eellular drugs accumulation resulting from active excretiou of dntg.
出处
《医学综述》
2006年第10期621-624,共4页
Medical Recapitulate
基金
天津市自然科学基金(033612311)
天津市高等学校科技发展基金(20030302)
关键词
肠球菌
氟喹诺酮类抗菌药
耐药
靶位改变
主动外排
Enterococci
Fluoroquinolones
Resistance
Target alterations
Active excretion
