1Ganey PE,Luyendyk JP,Maddox JF,et al.Adverse hepatic drug reactions:inflammatory episodes as consequence and contributor.Chem Biol Interact,2004,150:35-51.
2Ganey PE,Roth RA.Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents.Toxicology,2001,169:195-208.
3Eipel C,Bordel R,Nickels RM,et al.Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia.Am J Physiol Gastrointest Liver Physiol,2004,286:769-776.
4Devaux Y,Seguin C,Grosjean S,et al.Lipopolysaccharide-induced increase of Prostaglandin E (2) is mediated by inducible nitric oxide synthase activation of the constitutive cyclooxygenase and induction of membrane-associated Prostaglandin E synthase.J Immunol,2001,167:3962-3971.
5Jaeschke H,Farhood A,Fisher MA,et al.Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of beta 2 integrins and intercellular adhesion molecule-1.Shock,1996,6:351-356.
6Hewett JA,Jean PA,Kunkel SL,et al.Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury.Am J Physiol,1993,265:G1011-1015.
7Moulin F,Pearson JM,Schultze AE,et al.Thrombin is a distal mediator of lipopolysaccharide-induced liver injury in the rat.J Surg Res,1996,65:149-158.
8Katagiri H,Ito Y,Ishii K,et al.Role of throm boxane derived from COX-1 and-2 in hepatic microcirculatory dysfunction during endotoxemiain mice.Hepatology,2004,39:139-150.
9Ou J,Carlos TM,Watkins SC,et al.Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis,apoptosis,ICAM-1 expression,and neutrophil accumulation during endotoxemia.Nitric Oxide,1997,1:404-416.
10Laskin DL,Pilaro AM.Potential role of activated macrohages in acetaminophen hepatotoxicity.I.Isolation and characterization of activated macrohages from rat liver.Toxicol Appl Pharmacol,1986,86:204-215.
