摘要
背景与目的:探讨bcl-2、bax在不同类型子宫内膜腺上皮细胞中的表达。材料与方法:采用免疫组化检测不同类型子宫内膜组织中各指标的表达。结果:从单纯性、复杂性到不典型增生,bcl-2和bax的表达评分均有逐渐增多趋势,不典型性增生与前二者相比差异均有统计学意义。在内膜样腺癌中,随着分化程度的降低、分期的增加,bcl-2表达评分下降,且差异均有统计学意义。随着分化程度的降低bax蛋白的表达逐渐降低;随着浸润深度的增加,bax蛋白表达逐渐增加,各组间比较差异有统计学意义。在增生期和分泌期bcl-2和bax的表达无负相关,但在内膜样腺癌组织中bcl-2表达与bax呈正相关。结论:bcl-2和bax参与了癌前病变的发生。在内膜样腺癌中,bcl-2的表达与癌细胞分化程度、手术病理分期关系密切;bax表达与癌细胞的分化程度、肌层浸润深度有关。推测bcl-2、bax表达水平在一定程度上反映了肿瘤的生物学行为,可作为预测预后的指标。bcl-2和bax在增生期和分泌期内膜变化中虽有一定的作用,但二者相互作用关系不大;bcl-2与bax可能共同作用参与了内膜样腺癌的发生与发展。
BACKGROUND ＆ AIM： To analyze the expression of bcl-2 and bax in various endometral glandular epithelial cells. MATERIAL AND METHODS： We applied immunohistochemistry technique to detect bcl-2 and bax expression in various endometriial tissues. RESULTS： bcl-2 and bax expressious increased in tissues from simple hyperplasia（SH）,complex hyperplasia（CH） to atypical hyperplasia（AH）, bcl-2 and bax are higher in AH than SH and CH, and the differences were significant. In the endometrioid adenocarcinoma （EAC）, bcl-2 expression was associated with the differentiation grades（DG） and surgical pathological stages.As for bax,its eapression decreased with poorer differentiation grades but increased with deeper myometrial invasion（DMI） . bcl-2 expression had no negative correlation with bax, but there was a positive correlation between expressions of bcl-2 and bax in EAC. CONCLUSION： bcl-2 and bax might participate in the of precancerous lesions. In EAC, bcl-2 expression was associated with the DG and surgical pathological stages, bax expression was associated with DG and DMI. So to a certain extent,bcl-2 and bax expression might reflect the DG and biological behavior. They could be important parameters for the prognosis of patients.bcl-2 and bax jointly played important roles in the development of EAC.
出处
《癌变．畸变．突变》
CAS
CSCD
2006年第3期240-244,共5页
Carcinogenesis,Teratogenesis & Mutagenesis
