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乳腺癌组织中p51基因的表达及其意义 被引量:1

Expression and Significance of P51 Gene in Breast Cancer
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摘要 背景与目的:研究p51基因与乳腺癌的关系。材料与方法:应用末端脱氧核苷酸转移酶介导的dUTP缺口末端标记(Terminaldeoxynucleotidyltransferasebiotin-dUTPnickendlabeling,TUNEL)、RT-PCR等技术检测乳腺癌组织p51基因的表达及其与细胞凋亡、激素受体的关系。结果:乳腺癌(45例)组织p51基因表达(46.7%)高于良性乳腺病变(35例)组织(11.4%);淋巴结转移阳性者p51基因表达(90.5%)明显高于阴性者(8.3%);p51基因表达与雌激素、孕激素受体无相关性(P>0.05);p51基因表达阳性的肿瘤细胞凋亡率与阴性细胞差异无统计学意义(P>0.05)。结论:P51基因表达增多可能与乳腺癌发病及转移有关。 BACKGROUND & AIM: To investigate the changes of p51 gene in breast cancer. MATERIAL AND METHODS: The expression of p51 gene in breast cancer tissues was detected by Terminal Deoxynucleotidyl Transfemse Biotin-dUTP Nick End Labeling(TUNEL) and reverse transcriptase-PCR(RT-PCR), and the relationship between p51 gene and apoptosis and hormone receptors was analysed. RESULTS: The expression of p51 gene was significantly higher in breast cancer(21/45) than that in benign breast tumors(4/35) (P=0.001 ).It was also was significantly higher in of lymph nodes positive metastasis(19/21) than in negative ones(2/24) (P=0.006) .The expression of p51 gene is notrelated with ER("ER positive"13/27,"ER negative"8/18 P=0.807) ,PR("PR positive" 11/23,"PR negative" 10/ 22 P = 0.873);The apoptosis rate of p51 gene positive cells(9.73 ± 1.54) was not significantly different from the negativeones (9.90± 1.36)(P 〉 0. 05). CONCLUSION: The increasing expression of p51 gene may be related to breast cancer and its metastatic ability.
出处 《癌变.畸变.突变》 CAS CSCD 2006年第3期249-251,共3页 Carcinogenesis,Teratogenesis & Mutagenesis
基金 温州市科技发展计划项目(No.S2001A29)
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参考文献10

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二级参考文献23

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