期刊文献+

蛋白质组学在卵巢癌诊治中的研究进展

下载PDF
导出
摘要 蛋白质组是指基因组表达的所有蛋白质。蛋白质组学的核心在于大规模地对蛋白质进行综合分析,对蛋白质所执行的生理性、病理性生命活动做出最精细、最本质的阐述。其研究内容分为表达蛋白质组和功能蛋白质组两大类。蛋白质组学对卵巢癌具有广阔的临床应用前景,不仅有利于寻找较特异的肿瘤标志物用于卵巢癌的早期筛查,而且对于寻找新的卵巢癌治疗靶点、阐明卵巢癌发生发展机制都将产生巨大影响。
作者 赵群 邓小虹
出处 《癌变.畸变.突变》 CAS CSCD 2006年第3期252-254,共3页 Carcinogenesis,Teratogenesis & Mutagenesis
  • 相关文献

参考文献21

  • 1Blackstock W, Mann M. Aboundless future for proteomics[J] . Trends Biotechnol, 2001, 19(suppl): sl-s2.
  • 2Tragas C, Pawliszyn J. On line coupling of high performance gel filtration chromatography with imaged capillary isoelectric focusing using a membrane interface[J]. Electrophoresis, 2000, 21():227-237.
  • 3O' Farrell PH. High resolution two dimensional electrophoresis of proteins[J]. J Biol Chem, 1975, 250(): 4 007-4 021.
  • 4Nordhoff E, Ingendoh A, Cramer R, et al. Matric assisted laser desolption/ ionization mass spectrometry of nucleic acids with wave lengths in the ultraviolet and infrared[J] .Rapid Commun Mass Spectrom 1992, 6(): 771-776.
  • 5Bonner RF,Emmert BM, Cole K, et al. Laser capture microdissection:Molecular analysis of tissue[J].Science,1997, 278(): 1 481-1 483.
  • 6Mills GB, Bast RCJr,Srivastava S.Future for ovarian cancer screening:novel markers from emerging technologies of transcriptional profiling and proteomics[J]. J Natl Cancer Inst,2001,93():1437- 1 439.
  • 7Petricoin EF, Ardekani AM, Hitt BA, et al. Use of proteomic patterns in serum to identify ovarian cancer[J]. Lancet, 2002, 359(9306) :572 - 577.
  • 8Ye B, Cramer DW, Skates SJ, et al. Haptoglobin alpha-subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass pectrometry[J] . Clin Cancer Res, 2003, 9:2904-2941.
  • 9Ott HW, Lindner H, Sarg B. et, al. Calgranulins in cystic fluid and serum from patients with ovarian carcinomas[J]. Cancer Res ,63(21) :7 507 - 7 514.
  • 10Sorace JM, Zhan M. A data review and reassessment of ovarian cancer serum proteomic profiling[J]. BMCBio informatics, 2003, 4(1) : 24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部