摘要
目的探讨不同孕周的50g葡萄糖负荷试验(50gGCT)对筛查妊娠期糖尿病(GDM)的临床意义以及与孕妇年龄、体重及孕龄的关系。方法回顾性分析2004年1月￣2005年6月在该院门诊接受糖筛查的孕妇4043例,按孕龄分为3组:孕<24周组(A组),孕24￣28周组(B组),孕>28周组(C组),对GCT阳性的全部通过75g糖耐量(OGTT)试验,根据血糖结果又分为3组:正常组,OGTT异常组:糖耐量受损组IGT,GDM组,就研究项目根据孕妇年龄和体重因素,进行分组对照研究。结果GCT与OGTT异常检出率不同的孕周B组与C组对照无显著性差异(P>0.05),与A组对照差异有显著性(P<0.05);GCT和OGTT异常检出率不同年龄组,不同体重组分别比较,差异有显著性,(P<0.05),25岁以下无GDM高危因素的孕妇GDM发生率显著低于年龄≥25岁的孕妇。孕妇的平均体重指数(BMI)≥25.1时GCT异常率和GDM发生率均显著高于BMI<25.1者。结论对孕妇24周后行50g葡萄糖筛查均适宜而不仅限于24￣28周;孕妇年龄和体重与GDM发生密切相关,是GDM发生的高危因素,对肥胖或高龄孕妇应尽早行GCT筛查;25岁以下无高危因素者可不必常规筛查。
[Objective] To study the clinic value of the 50 g oral glucose challenge test （GCT） to screen the gestational diabetes mellitus （GDM） in different pregnant weeks, and to study the relationships of maternal age and body weight to GDM. All women were divided into three groups： less than 24 weeks of gestation group （A group）, 24-28 weeks of gestation group （B group） and more than 28 weeks of gestation group （C group）. 75 g oral glucose tolerance test （OGTT） were performed in all the women who were positive in GCT and they were divided into three groups： normal group, Glucose intolerance （IGT） group, GDM group. A control study of were made based on age and weight. [Methods] The clinical data of 4 043 pregnant women who underwent the GCT from January 2004 to June 2005 in out-patient clinic of our hospital were collected, and a retrospective study was made. [Results] （1） We compared B group to A group, there were no significant difference of the abnormal rate of GCT and GDM, but when compared B group to C group, there were significant difference （P 〈0.05）. （2） There were significant difference of the abnormal rate of GCT and GDM when compared age and weight （P 〈0.05）. The incidence rate of GDM of pregnant women younger than 25 years old without high risk factors was significantly lower than women older than 25 years. The incidence rate of GCT and GDM of pregnant-women whose BMI were no less than 25.1 were significantly higher than those BMI lower than 25.1. [Conclusions] （1） It is suitable to screen GDM after 24 weeks of gestation not only for 24 to 28 weeks. （2） Age and weight of pregnant women are the important risk factors for the GDM. It is necessary to screen GDM as soon as possible for pregnant women with obesity or older age. （3） It is not necessary to screen GDM among the pregnant women younger than 25 years old without high risk factors.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第9期1404-1406,共3页
China Journal of Modern Medicine
关键词
孕周
年龄
体重
糖筛查
糖耐量
妊娠期糖尿病
妊娠期
pregnant weeks
age
weight
glucose screening
glucose tolerance
gestational diabetes mellitus
