摘要
目的:建立中药产品中苯、甲苯、二甲苯、苯乙烯、二乙苯、二乙烯苯、萘、癸烷、十一烷和十二烷共10种大孔吸附树脂有机残留物的检测方法。方法:采用气相色谱法,以二氯甲烷为提取溶剂,以 DB-624毛细管柱(30 m×0.32 mm,1.8μm)分离、氢火焰离子化检测器检测。结果:10种有机残留物在12 min 内能很好地分离;各有机残留物的加样回收率(n=3)为61.4%～109.2%,其 RSD 在0.62%～14%;精密度为1.3%～4.4%,最低检测限为0.007～0.03μg·mL^(-1)。检测的3种中药产品中均未检出各有机残留物。结论:该方法能够同时检测10种有机残留物,并具有分离度高、快速、简便、灵敏和准确等特点。
Objective： To develop a method for detection the organic solvent residues including benzene, toluene, xylene, styrene, decane, diethylbenzene, undecane, divinylbenzene, dodecane and naphthalene from macroporous adsorption resin in Traditional Chinese Medicine（TCM） products. Method： The organic residues were extracted from TCM with dichloromethane. Benzene and the nine organics were analyzed by gas chromatography using a DB -624 capillary column（30 m ×0. 32 mm,1.8μm） and a FID. Results： All the 10 organic residues were well separated in 12 minutes. The recoveries of organics（ n = 3 ） were 61.4% - 109.2%, RSD 0. 62% - 14%. The precisions were 1.3% -4. 4%. The limits of detection were 0. 007 -0. 03μg · mL^-1. None of the organics were detected in three TCM products. Conclusion： Ten organic residues can be And the method is sensitive and accurate. detected simultaneously and rapidly with high resolution.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2006年第4期438-442,共5页
Chinese Journal of Pharmaceutical Analysis
基金
"十五"国家科技攻关项目(2001BA701A02)
关键词
气相色谱法
中药
有机残留物
大孔吸附树脂
GC
Traditional Chinese Medicine （TCM）
organic solvent residues
macroporous adsorption resin
