摘要
目的:探讨层粘连蛋白(Laminin,LN)和受体(LamininReceptor,LN-R)的表达在葡萄胎预后中的意义。方法:应用免疫组化方法对41例葡萄胎组织(经随访13例发生恶变)和20例正常早孕绒毛组织中LN及LN-R进行检测。结果:LN在正常绒毛、葡萄胎未恶变组和恶变组中的强表达率分别为,90.0%(18/20)、71.4%(20/28)、38.5%(5/13);LN-R分别为70.0%(14/20)、71.4%(20/28)、84.6%(11/13)。LN表达葡萄胎预后恶变组显著高于其他两组。结论:LN和LN-R在葡萄胎中的表达可能在葡萄胎恶变过程中起重要作用,有望作为判断葡萄胎预后的参考指标之一。
Objective： To investigate the significance of laminin （LN） and laminin receptor （LN-R） in the proceeding and prognosis of hydatidiform mole. Methods： Immunohistochemical SP staining was used to detect the expression of LN and LN-R in 41 hydatidiform mole cases （13 cases were learned to have turned malignant by following up）. 20 cases of normal early gestational chorion were detected as control. Results： The strong positive rates of LN and LN-R in normal chorion, hydatidiform mole un-malignant group and malignant group were respectively 90.0% （18/20）, 71.4% （20/28）, 38.5% （5/13）, and 70.0% （14/20）, 71.4% （20/28）, 84.6% （11/13）. The strong expression of LN had a significant difference between malignant group and the other 2 groups （P 〈 0.05）. Conclusion： LN and LN-R may play an important role in malignant proceeding of hydatidiform mole. Detection of LN and LN-R may be of great value in assessing the prognosis of moles.
出处
《重庆医科大学学报》
CAS
CSCD
2006年第3期373-376,共4页
Journal of Chongqing Medical University
