摘要
为了探讨人脊髓损伤后再生过程，用免疫组织化学及电镜等方法研究了２１例脊髓创伤后存活２小时至５４年患者的脊髓尸检材料。结果表明：创伤后４天，损伤的脊髓组织内便可见再生的轴突支芽。创伤４．５个月以后，损伤的脊髓内出现许多轴突再生巢。巢内含有定向排列的轴突及施万细胞，部分轴突已被施万细胞形成的髓鞘所包绕。巢内施万细胞表达了神经生长因子受体（ＮＧＦＲ）。此外，受损平面脊神经根内，施万细胞的ＮＧＦＲ表达增强。以上结果表明：人脊髓创伤后有积极的再生过程，施万细胞的ＮＧＦＲ可介导神经生长因子，支持并引导中枢性轴突的再生。
InordertoinvestigatetheregenerationoftheaxonsandtheefectsofSchwanncelsandthenervegrowthfactorreceptors(NGFR)onregenerating,21autopsymaterialsofthespinalcordsfromthepatientswithsurvivalperiodsfrom2hoursto54yearsafterspinalcordtraumawerestudiedwiththemethodsofimmunohistochemistryandelectronmicroscopy.Theresultsshowedthattheregeneratingsproutsoftheaxonscouldbeobservedasearlyas4daysaftertrauma.4.5monthsaftertrauma,manyregeneratingnestsofaxonsappearedintheinjuriedspinalcord.TheregenerationnestcontainedthedirectionalyarangedaxonsandSchwanncelswithwhichsomeaxonsweremyeli-nated.TheSchwanncelsexpressedtheNGFR.TheSchwanncelswithinthespinalnerverootsattheinjuriedlevelexpressedincreasedpositiveNGFR.Theseresultssuggestedthattheactivelyre-generatingproceshappenedinthetraumaticalyinjuriedhumanspinalcord.TheNGFRexpressedonSchwanncelscouldmediateNGFtosupportandinducetheaxonregenerationintheCNS.
出处
《中华神经科杂志》
CSCD
1996年第4期237-240,共4页
Chinese Journal of Neurology
关键词
轴突再生
神经生长因子
许旺细胞
脊髓损伤
创伤
HumanSpinalcordtraumaAxonregenerationNervegrowthfactorre-ceptorsSchwanncel
