摘要
目的:探讨中国湖北汉族慢性荨麻疹(CU)的发生与HLA-DRB1、DQB1等位基因间的关系。方法:应用聚合酶链反应-序列特异性引物(PCR-SSP)技术对已经确诊的湖北汉族CU42例和正常对照组193例进行HLA-DRB1、HLA-DQB1基因多态性分析。结果:患者组HLA-DRB112、0901等位基因频率较正常对照组显著增高(RR=3.11,χ2=7.579,P=0.006;RR=2.47,χ2=5.684,P=0.017),HLA-DQB105等位基因频率较正常对照组显著降低(RR=0.26,χ2=6.683,P=0.01)。结论:CU与HLA-DRB112、0901以及HLA-DQB105等位基因关联,前者是中国湖北汉族人CU的易感基因,而后者对CU有抵抗性。
Objective： To determine the association of genotypes of HLA - DRB1 and DQB1 alleles with chronic urticaria. Methods： Genotypes of HLA - DRB1, HLA - DQB1 genes were detected by polymerase chain reactions with sequence-specific primers （PCR- SSP） in 42 patients with chronic urticaria and 193 racially matched healthy controls. Results： Gene frequencies of HLA - DRB1＊ 12,＊0901 were significantly increased in chronic urticaria patients as compared with healthy people （ RR = 3.11, χ^2 = 7. 579, P = 0. 006; RR = 2.47, χ^2 = 5. 684, P = 0.017）. Gene frequencies of HLA - DQB1＊ 05 were significantly decreased in chronic urticaria patients（RR = 0.26,χ^2 = 6.683,P=0.01）. Conclusion： Chronic urticaria was strongly associated with HLA- DRB1＊12, 0901 and HLA - DQB1＊05, which suggests that the former may be the genetic markers for susceptibility to CU, but the latter may play a resistant role.
出处
《中国麻风皮肤病杂志》
2006年第5期369-371,共3页
China Journal of Leprosy and Skin Diseases
