摘要
目的:观察豆根管食通口服液治疗食管癌的近期疗效。方法:食管癌患者60例,随机均分为2组。治疗组给予“豆根管食通口服液”10ml口服,3次/d,对照组给予替加氟片200mg口服,3次/d,1个月为1疗程,共治疗2个疗程。观察治疗前、第1疗程后、第2疗程后2组一般状况、症状体征及生活质量,检测血清IL-6、IL-10的变化,并比较2组的临床疗效。结果:2组治疗后,一般状况、症状体征及生活质量均较治疗前改善(P<0.05或0.01),且治疗组优于对照组(P<0.01)。与对照组相比,治疗组治疗后血清IL-6水平升高,IL-10下降。治疗组治疗2疗程后的总有效率高于对照组(46.7%vs23.3%,P<0.05)。结论:豆根管食通口服液能明显改善食管癌患者的一般状况和症状体征、提高患者的生活质量,减轻患者的临床症状,可能与其升高血清IL6水平,降低IL10水平有关。
Aim ： To study the effect of Dougenguanshitong oral liquid in treatment of esophageal carcinoma. Methods ： A total of 60 cases of esophageal carcinoma were randomly divided into 2 groups. Treatment group was given Dougenguanshitong oral liquid, 3 times per day, the control group was given an anti-tumor drug, 3 times per day. The general condition, clinical symptoms and qualify of life of the 2 groups were observed, and the serum IL-6 and IL-10 were determined before treatment, at the end of 1 month and 2 months treatment. Results： After treatment, the general condition, clinical symptoms, and qulity of life in 2 groups were both improved （P 〈 0.05 or 0.01 ） , and those of treatment group were better （P 〈 0.01 ）. Compared with control group, the serum IL-6 increased and IL-10 decreased. The total effective rate in treatment group was higher than that in control group after 2 months treatment （46.7% vs 23.3% , P 〈 0.05 ）. Conclusion： Dougenguanshitong oral liquid can improve the general condition, symptoms and quality of life, which may involve in its increasing serum IL-6 and decreasing IL-10.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2006年第3期494-496,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省科技攻关基金资助项目001170712
郑州大学"211"工程基金资助项目
