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全静脉麻醉与静吸复合麻醉用于脊柱侧弯矫正术中唤醒的比较 被引量:8

Comparison of the effects of total intravenous anesthesia and combined inhalation and intravenous anesthesia on awakening test in correction surgery of scoliosis
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摘要 目的比较脊柱侧弯矫正术中,全静脉麻醉与静吸复合麻醉的术中唤醒时间及苏醒质量。方法40例择期脊柱侧弯矫正术患者,ASAⅠ~Ⅱ级,随机均分为两组:全静脉麻醉组(静脉组)和静吸复合麻醉组(静吸组)。术中麻醉维持,静脉组靶控输注异丙酚,效应部位靶浓度2-4μg/ml;静吸组吸入笑气(N2O:O2:1:1),异氟醚浓度为0.8%~1.5%,两组均靶控输注瑞芬太尼,效应部位靶浓度2-6ng/ml。观察停止输注异丙酚或吸人麻醉药后术中唤醒时间及唤醒质量。结果静脉组唤醒时间为19.7±5.1min,而静吸组为11.9±3.3min(P〈0.05)。唤醒成功时,静脉组有3例睁眼勉强,并伴有四肢不自主活动,苏醒质量为Ⅱ级;静吸组均为Ⅰ级。结论术中维持相同的循环指标,静吸组唤醒时间要短于静脉组,静吸组唤醒质量要优于静脉组。 Objective To study the effects of total intravenous anesthesia and combined inhalation and intravenous anesthesia on arousing time and recovery quality in rectifying surgery of scoliosis,Methods Forty patients (ASAⅠ-Ⅱ) were divided randomly into total-intravenous anesthesia group and combined inhalation and intravenous anesthesia group (n=20 each). Target controlled infusion (TCI) with propofol (2-4μg/ml) was used for maintenance in total intravenous anesthesia group, while isoflurane (0. 8%-1.5%) and nitrous oxide (50%) were used in combined inhalation and intravenous anesthesia group. TCI remifentanyl (2-6ng/ml) was used for maintenance in both groups. Results Arousing time were 19.7±5. 1min in total intravenous anesthesia group, but 11.9±3. 3 min in combined inhalation and intravenous anesthesia group (P〈0. 05). When arousing was successful, non-autonomous movements of limbs were found in three patients with difficulty in opening of eyelids in the total intravenous anesthesia group. Conclusions Combined inhalation and intravenous anesthesia in the surgery for correcting scoliosis can significantly shorten the time of arousing with the fewer side effects and higher quality of arousing.
出处 《解放军医学杂志》 CAS CSCD 北大核心 2006年第5期480-481,共2页 Medical Journal of Chinese People's Liberation Army
关键词 唤醒试验 全静脉麻醉 静吸复合麻醉 靶控输注 awaken test total-intravenous anesthesia, inhalational combined with intravenous anesthesia, target-controlled infusion
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  • 1Schnider TW,Minto CF,Carnbus PL et al.The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.Anesthesiology,2000,93(6):1557.
  • 2Minto CF,Schnider TW,Egan TD et al.Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil.I.Model development.Anesthesiology,1997,86(1):10.

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