摘要
目的:从中医经络学说方向探讨被认为是绝大部分组织再生的本源组织特异性干细胞与中医经络系统的联系。方法:参阅《黄帝内经》、《难经》、《奇经八脉考》等中医经典理论著作及现代经络理论著作,从中医经络学说方向揭示干细胞巢在组织中的分布规律,用实验动物验证中医经络学说。结果:不同种类干细胞巢的有序分布构成中医经络系统:①唯有不同种类的成体干细胞等所在的干细胞巢,才具有高度统一的、高度稳定性的细胞团结构,也就是说干细胞自我增殖形成的细胞团结构是相同相似的。②治本时所需的较长时间与成体干细胞自我复制及其产生健康的各级分化细胞所需的较长时间是一致的。③《黄帝内经》中经脉、络脉的分类即是成体干细胞巢的分类。人体成体干细胞分化产生3个等级的定向干细胞。国外众多的研究报告称少数的癌症干细胞才是肿瘤的来源,大多数的癌细胞并不能生长成为新的肿瘤。④胚胎发育的早期,干细胞与祖细胞彼此协同地增殖分化,不存在3个等级的定向干细胞,不存在普适统一的干细胞巢结构。此后,干细胞巢中的成体干细胞成为组织再生的本源,经络系统中有规律性迁移的细胞主要是定向干细胞,其次为成体干细胞,其中,易变异成为癌细胞的定向干细胞为最少。⑤针灸必然会破坏乃至驱散干细胞巢,但诸细胞组分将重新形成新的干细胞巢,其中的成体干细胞一般会出现超补偿性自我增殖,分化产生更多的健康的定向干细胞,后者分化产生更多的健康的分化细胞,使得相应组织的结构与功能恢复至良性状态。结论:经络学说深刻地揭示了干细胞巢是一个复杂开放的微系统,即外来的定向干细胞和成体干细胞的种类不是固定不变的,不是局域性的,而是既有基本稳定不变的静态成分,又有复杂可变的动态成分,是整体性的,并且两者在物种进化史上是可以相互转化的。
AIM： To investigate the correlation of tissue specific stem cells regarded as original source of regeneration for an absolute majority of tissues and the system of channels and collaterals. METHODS： Referring to traditional classic theoretic works Yellow Emperor＇s Internal Classic, Yellow Emperor＇s Eighty-one Difficult Classic, An Examination of the Eight Extra Meridians and modern theoretic works about channel and collaterals, we revealed the distributional law of stem cell niche in the tissue according to the theory of traditional Chinese medicine （TCM） and verified the TCM theory of channels and collaterals by animal experiment. RESULTS： TCM system of channels and collaterals was constituted by different kinds of stem cell niche in ordinal distribution： ①Only the stemcell niche, where different types of adult stem cell were found, has a highly unified and stabilized structure of cell aggregation; In other words, the structures of the cell aggregations formed through self-proliferation of stem cells are similar or identical. ②The time for the treatment of the origin of disease is the same longer as the time for the self-duplication of the adult stem cells and their generation of healthy cells through differentiation at different levels. ③The classification of channels and collaterals in the Yellow Emperor＇s Internal Classic corresponds to that of the adult stem dells. The adult stem cells generate three grades of committed stem cells after differentiation. Many abroad researchers reported that only a few cancer stem cells were the source of cancer, whereas many cancer cells could not grow into new cancer.④At the initial stage of embryo growth, stem cells and the progenitor cells proliferate and differentiate in coordination and there does not exist the three types of committed stem cells, nor does the universally unified structure of stem cell niche. Afterwards, the adult stem cells in the stem cell niches become the original source of the tissue regeneration. The cells that regularly migrate in the system of channels and collaterals are mainly the committed stem cells, adult stem cells are the next and the second type of committed stem cells that are easy to form cancer cells are the least. ⑤Acupuncture will inevitably damage and even dismiss the stem cell niches but those cell components will reform new stem cell niches. And adult stem cells in the new niches may normally show self-proliferation in an ultra-complimentary way to generate more healthy Committed stem cells through differentiation and the second type of committed stem cells generate more healthy differential cells through differentiation so as to make the corresponding tissue structure and function recovered to the benign state.
CONCLUSION： The theory of channels and collaterals has profoundly revealed that the stem cell niche is a complex and open micro system; that is, the types of exotic committed stem cells and adult stem cells are not stable. It has both the static quality of being Stable without change and the dynamic state of being complex and changeable. And, in the evolutionary history of species, both can be inverted into each other.
出处
《中国临床康复》
CSCD
北大核心
2006年第21期189-192,共4页
Chinese Journal of Clinical Rehabilitation
