摘要
目的:探讨妊娠期肝内胆汁淤积症(ICP)患者脂质过氧化和抗氧化状态。方法:分别用硫代巴比妥酸和亚铁嗪显色分光光度法测定30例ICP患者治疗前和治疗后及42例健康孕妇血清MDA和维生素E水平。结果:ICP患者治疗前血清MDA(17.67±12.14nmol/L)和维生素E(2.77±1.58mmol/L)水平均显著高于健康孕妇组(7.57±1.30nmol/L,1.18±0.74mmol/L,P<0.01)。常规治疗1周后,ICP患者血清MDA(15.22±9.58nmol/L)水平略有下降,但仍显著高于健康孕妇组(P<0.01),而维生素E(2.91±1.56mmol/L)水平则略有上升。结论:ICP患者体内脂质过氧化作用明显增强,抗氧化作用代偿性增强严重不足;维生素E是否可用于ICP治疗尚待研究。
Objective： To investigate the lipid peroxidative and anti-oxidative status of patients with intrahepatic cholestasis of pregnancy （ICP）. Methods：Serum was collected from 42 healthy women with late pregnancy and 30 women with ICP before and after regular treatment. MDA and vitamin E were colorated with thiobarbituric acid and ferrospectral, respectively, and determined by spectrophotometry. Results： Serum MDA （ 17.67 ± 12.14 nmol/L） and vitamin E （2.77 ± 1.58 mmol/L） of ICP patients were significantly higher than healthy pregnant women （7.57 ± 1.30 nmol/L,1.18 ± 0.74 mmol/L, P 〈 0.01 ）. After one week regular treatment, serum MDA （ 15.22 ± 9.58 nmol/L） of ICP patients decreased slightly, but vitamin E （2.91 ± 1.56 mmol/L） increased a little. Conclusions; lipid peroxidation of ICP patients increased significantly, but the compensatory elevation of anti-oxdation was not enough. Vitamin E is maybe a new choice for treatment of ICP.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2006年第5期303-305,共3页
Journal of Practical Obstetrics and Gynecology
关键词
妊娠期肝内胆汁淤积症
脂质过氧化
维生素E
Intrahepatic cholestasis of pregnancy （ICP）
Lipid peroxidation
Vitamin E
