摘要
目的 观察制何首乌对大鼠的长期毒性作用。方法 用制首鸟水煎浓缩液，每天按不同剂量灌服大鼠1次，连续3—3．5个月。结果 各给药组肉眼观察可见部分肝脏表面有脂肪颗粒，病理切片显示有不同程度的脂变、肝血窦扩张充血，偶见炎细胞浸润。各剂量组给药期间大鼠精神较差，进食量减少。体重增加较慢。停药后均减轻或消失。结论 制何首鸟长期灌胃对大鼠肝脏有一定的毒副作用。
Objective To observe the long - term toxification of Prepared Radix Polygoni Multiflori to the Rats. Method The rats were infused with condensed Prepared Radix Polygoni Multiflori decoction, different dosages once a day , 3～3.5 months. Results Fat granular has been found on part of the liver surface in each group with naked eyes. The pathologic section shows fatty generation, hepatic sinusoid dilated congestion in different degrees, infiltration inflammatory cell sometimes. During medication rats＇ spirit condition were relatively poor, with poor appetite, slow rate of gaining weight, which had been relieved or disappeared when the medication stopped. Conclusion Prepared Radix Polygoni Multiflori has some side effect on the rats＇ liver.
出处
《陕西中医学院学报》
2006年第3期40-41,F0003,共3页
Journal of Shaanxi College of Traditional Chinese Medicine
基金
陕西省教育厅科研基金项目(02JK069)
关键词
制何首鸟
毒生
肝损害
Prepared Radix Polygoni Multiflori
Toxification
Liver injury.
