摘要
以(R)-(+)-pu legone为起始原料,经1,4-加成,还原两步反应合成了手性辅助试剂(+)-(1S,2S,5R)-8-联苯薄荷醇及其差向异构体(-)-(1R,2S,5R)-8-联苯薄荷醇,总产率95%。其结构经1H NMR,13C NMR,IR,MS和X-射线衍射仪表征。
The chiral auxiliary （ ＋ ） - （ 1 S, 2S,5 R） -8-biphenylmenthol and its epimer （ - ） - （ 1R,2S, 5R）-8-biphenylmenthol in total yield of 95% were synthesized by the reaction of 1,4-addition and reduction from （R）-（ ＋ ）-pulegone. The structures were confirmed by ^1H NMR, ^13C NMR, IR, MS and XRD.
出处
《合成化学》
CAS
CSCD
2006年第3期278-280,286,共4页
Chinese Journal of Synthetic Chemistry
