摘要
目的观察盐酸吗啡缓释片对中重度癌性疼痛的镇痛疗效。方法盐酸吗啡缓释片30mg／12h开始给药，然后根据镇痛效果调整剂量，不能缓解者按25％-50％逐渐加量至患者感到舒适为止，最小剂量60mg／d，最大剂量600mg／d。结果56例中，癌性疼痛完全缓解13例（23．2％）；明显缓解17例（30．4％）；中度缓解2l例（37．5％）；轻度缓解及无效5例（8．9％）；总缓解率为91．1％。治疗前后生活质量评分各平均为32．21±5．80和49．27±5．62，二者比较差异有统计学意义（P〈0．05）。不良反应只须对症处理，束发现药物依赖性。结论盐酸吗啡缓释片能有效控制癌性疼痛，提高癌症患者的生活质量。是治疗癌性中熏度疼痛的理想药物。
Objective To observe the efficacy on the treatment of moderate-severe cancer pain by morphine hydrochloride sustained release tablets. Methods The beginning dosage of morphine hydrochloride sustained release tablets was 30 mg every 12 hours, The dosage should be adjusted according to the pain-ease effect, those who could not be remitted were given 25% to 50% extra dosages till feeling comfortable. The minimum dosages were 60mg per day, while the maximum 600mg. Results Among 56 patients with moderate-severe cancer pain, 13 （23.2 % ） were completely relieved, 17 （30.4 % ） were significantly relieved, and 21 （37.5 % ） were moderately relieved, while 5 （8.9 % ） slightly or inefficiently relieved, The total effective rate was 91.1% （51/56） .The mark of life quality increased from 32.21 ± 5.80 to 49.27 ± 5.62 （ P 〈 0.05）. The common sideeffects were constipation, nausea, vomiting and dizziness, which were easy and safe for aimed treatment without drug addiction. Conclusions Morphine hydrochloride sustained release tablets were effective on the treatment.of cancer pain, and capable of improving cancer patients＇ life quality. They should be the first selective medicine for the treatment of moderate-severe cancer pain.
出处
《肿瘤基础与临床》
2006年第3期229-230,共2页
journal of basic and clinical oncology
关键词
盐酸吗啡缓释片
癌痛
中重度
疗效
Morphine hydrochloride sustained release tablets
cancer pain
moderate-severe
therapy efficiency
