期刊文献+

PTEN、CyclinE与子宫内膜癌 被引量:1

下载PDF
导出
摘要 子宫内膜癌是女性生殖系统中常见的恶性肿瘤,近年来,由于内环境、外环境各方面的影响,发现该肿瘤的发病率有所上升,并且发病的年龄较以往呈年轻化,对女性的健康质量威胁很大。然而,它的发病机制至今尚未清楚,随着分子生物学研究的不断进展和突破,已知子宫内膜癌与其它恶性肿瘤一样,本质是细胞生长周期调节失控,细胞呈无限制、自主增生和分裂。这些收获为探讨和发现子宫内膜癌的发生和发展提供了新的途径和依据。
出处 《柳州医学》 2006年第2期101-104,共4页
基金 广西卫生厅医疗卫生科研立项课题(合同号:Z2004057)内容。
  • 相关文献

参考文献1

二级参考文献7

  • 1[1]Li J,Yen C,Liaw D,et al. PTEN,a putative protein tyrosine phosphatese gene mutated in human brain,breast,and prostate cancer [J]. Science,1997, 275:1943- 1947.
  • 2[2]Constantine A,Monteagado O,Merino HJ,et al. Immunohisto- chemical detection of P- glycoprotein in endometrial adenocarcinoma [J]. Am J Pathol,1991,138:799- 806.
  • 3[3]Tashiro H,Blazes MS,Wu R,et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies [J]. Cancer Res,1997, 57:3935- 3940.
  • 4[4]Kinzler KW,Vogelstein B. Cancer- susceptibility genes. Gatekeepers and caretakers [J]. Nature,1997, 386:761- 763.
  • 5[5]Teng DH,Hu R,Lin H,et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines [J]. Cancer Res,1997,57:5221- 5225.
  • 6[6]Mutter GL,Lin MC,Fitzgerald JT,et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers [J]. J Natl Cancer Inst,2000, 92:924- 931.
  • 7[7]Whang YE,Wu X,Suzuki H,et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression [J]. Proc Natl Acad Sci USA,1998, 95:5246- 5250.

共引文献27

同被引文献15

  • 1李长民,庄如锦,李佩玲,关咏梅.p27和cyclinE在宫颈癌中的表达及其临床意义[J].中国现代医学杂志,2005,15(11):1651-1654. 被引量:5
  • 2王巍,辛晓燕,刘玉,郭会玲.宫颈癌组织中HER-2/neu和Ras表达的意义[J].第四军医大学学报,2006,27(19):1805-1807. 被引量:6
  • 3Skomedal H, Kristensen GH, Lie AK, et al. Aberrant Expression of the Cell Cycle Associated Proteins TP53, MDM2, p21, p27, cdk4, Cyelin DI, RB, and EGFR in Cervical Carcinomas [J]. Gynecol Oncol, 1999, 73(2) : 223 - 228.
  • 4Donnellan R, Chetty AR. Cyclin E in human cancers [J]. FASEB, 1999,13 : 773 - 780.
  • 5Rosen DG, Yang G, Deavers MT, et al. Cyclin E Expression Is Correlated with Tumor Progression and Predicts a Poor Prognosis in Patients with Ovarian Carcinoma[J]. Cancer, 2006, 106(9) : 1925 - 1932.
  • 6Pruitt K, Pestell RG, Der CJ. Ras inactivation of the retinoblastoma pathway by distinct mechanisms in NIH 3T3 fibroblast and RIE - 1 epithelial cells[J]. Biol Chem. ,2000,275(52) :40916 - 40924.
  • 7Hitomi M,Stacey DW. Ras- dependent cell cycle commitment during G2 phase[J]. FESB Lett,2001,490:123- 131.
  • 8Prober DA, Edgar BA. Ras 1 promotes cellular growth in the Drosophila wing[ J]. Cell, 2000,100(4) :435 - 446.
  • 9Wingate H, Puskas A, Duong M, et al. Low molecular weight cyelin E is specific in breast cancer and is associated with mechanisms of tumor progression[J]. Cell Cycle, 2009,8(7) : 1062 - 1068.
  • 10周奇,粱力建,彭宝岗,甄宇洋,苏才坤.肝细胞癌中p27、cyclin E和cyclin A的表达及相关分析[J].中山大学学报(医学科学版),2006,27(B03):60-63. 被引量:5

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部