摘要
为研究替普瑞酮对慢性浅表性胃炎的疗效，用替普瑞酮对５３例慢性浅表性胃炎患者进行了治疗，结果显示：该药可有效地缓解临床症状，对上腹饱胀有效率为９０．９％，对上腹疼痛有效率为８７．２％。该药可改善胃粘膜组织病理学表现，慢性炎症好转率为３９．６％，活动性炎症消失率为１３．９％。还可显著提高胃粘膜氨基己糖水平（Ｐ＜０．０５），增加胃粘膜前列腺素Ｅ２含量（Ｐ＜０．０５）及胃粘膜血流量（Ｐ＜０．０５）。研究结果提示，替普瑞酮是一种安全有效。
Teprenone(Selbex),agastricmucosalprotectivedrugfortreatmentofchronicgastritisandgastriculcer,hasrecentlybeenusedinthePeople'sRepublicofChina.Teprenoneinthetreatmentofchronicsuperficialgastritis(CSG):asurveilancestudywasrecentlyconductedin4majorhospitalsinBeijing.Thestudyincluded98patients(teprenonegroup53patients,Merzulene-Sgroup45patients)withendoscopicalyprovengastritis.ThestudyshowedthatteprenonemayrelievesymptomsofCSGin8weeks.Theefectivenessrateforflatulencewas90.9%andforepigastralgia87.2%.Theimprovementrateforthechronicinflammationinhistopathologywas39.6%anddisappearanceratefortheactivityofinflammationwas13.9%.Itraisedsignificantlytheaminohexoselevelingastricmucosa(P<0.05)andincreasedgastricmucosalbloodflowingastricantrum(P<0.05).Thesedatasuggestthatteprenoneisasafeandefectivegastricmucosalprotectivedrug.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1996年第1期12-18,共7页
Chinese Journal of Internal Medicine
