摘要
目的:探讨抗β2-糖蛋白Ⅰ抗体(anti-β2-GPⅠantibody)与反复自然流产(RSA)的关系。方法:采用酶联免疫吸附法检测81例RSA患者和39例正常妇女血清中anti-β2-GPⅠ的水平。结果:RSA组anti-β2-GPⅠ及其IgG型抗体阳性率分别为42.0%和40.8%,显著高于对照组(7.7%)(P<0.01,P<0.05);IgM型抗体阳性率与对照组比较差异无显著性(P>0.05);早期与中晚期RSA两组间及RSA 2次与RSA≥3次两组间阳性率比较差异均无显著性(P>0.05)。结论:anti-β2-GPⅠ与RSA有关,可作为RSA免疫因素的辅助诊断指标。
Objective To explore the relationship between recurrent spontaneous abortion （RSA） and anti-β2- glycoprotein Ⅰ （anti-Ⅰ2-GP Ⅰ ） antibody. Methods The levels of anti-β2-GP Ⅰ antibody in serum from 81 RSA patients and 39 normal women were detected by ELISA. Results The positive rate of anti-β2-GP Ⅰ in RSA patients （42.0%） was obviously higher than that in normal women （7.7%） （P^0.01）; there was obvious difference of the positive rate of anti-β2-GP Ⅰ IgG in statistics between RSA patients （40.8%） and normal women （7.7%） （P〈0.05）, and there was no difference of the positive rate of anti-β2-GP Ⅰ IgM in statistics between RSA patients and normal women （P〉0.05）. There was no difference of the positive rate of anti-β2-GP Ⅰ in statistics between early and late, as well as between 2 times and more than 2 times abortions of RSA （P〉0.05）. Oonclusion The anti-β2-GP Ⅰ antibody is related to RSA, and it may be regarded as a immunological assistant diagnostic index for RSA.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2006年第3期486-488,共3页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅资助课题(990569)
关键词
流产
习惯性
抗β2-糖蛋白Ⅰ抗体
酶联免疫吸附测定
abortion, habitual
anti-β2-glycoprotein Ⅰ antibody
enzyme linked immunosorberent assay
