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榄香烯对多药耐药人红白血病细胞株的影响 被引量:7

Effect of β-elemene on multi drug resistance in K562/ADM cells
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摘要 [目的]探讨抗肿瘤药β-榄香烯对多药耐药细胞系的影响。[方法]利用MTT,荧光染料Hoechst33342染色、透射电镜的方法观察β-榄香烯对多药耐药性(mdr)人红白血病细胞株K562/ADM细胞的生长和凋亡的影响。[结果]β-榄香烯对K562/ADM细胞的抑制作用在5—40μg/mL的药物浓度范围内呈上升趋势,加药组24—72h范围内细胞凋亡率不断增加,浓度40μg/mL72h时达高峰62.73%±,二者呈现药物浓度和作用时间依赖性(P〈0.05或P〈0.01)。[结论]诱导细胞凋亡是β一榄香烯抗肿瘤细胞作用机制之一。 [ Objective] To investigate the inhibitory mechanism of β- elemene to multi drug resistance in K562/ADM cells. [ Methods] The growth and apoptosis of K562/ADM ceils treated with β - demene was determined by MTT, hoechst 33342 staining and electron microscope(EM). [ Results] The inhibitory affection and apoptotic rate significantly increased during treated with 5 - 40 μg/ mL for 24 -72 h of β- elemene ,the maximal inhibitory rate reached to 62.73% ± after treated 72 h( P 〈 0.05) .β- elemene have obvious affection of suppression growth and induce apoptosis to K562/ADM cells , which was depended on dose of drug and treated time to some extent. [ Conclusion] Induced apoptosis is one of its resistance tumor mechanism of β- elemene. ap
出处 《大连医科大学学报》 CAS 2006年第3期184-186,共3页 Journal of Dalian Medical University
关键词 细胞凋亡 Β-榄香烯 K562/ADM细胞系 多药耐药 optosis β - elemene K562/ADM cell line
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