摘要
目的:观察针刺结合药物治疗对帕金森病患者的干预效果及患者血浆和红细胞超氧化物歧化酶活性、过氧化脂质含量的变化。方法:选择2004-01/2006-02在浙江中医药大学附属针灸推拿医院针灸科就诊的帕金森病患者38例,均自愿参加观察。按随机数字表法分为两组,针药并用组和药物对照组各19例。①药物对照组口服苄丝肼-左旋多巴,62.5～500mg/次,2～4次/d,治疗时间同针药并用组。②针药并用组在药物对照组基础上加用针刺疗法,头皮针平刺法进针,捻转3min后接通电针,通电时间30min;体穴以平补平泻手法,留针30min。隔日1次,10次为1个疗程,疗程间休息7d,治疗时间为4个疗程。采用统一帕金森病评定量表进行临床疗效评定,分别于治疗前及治疗2,4个疗程后进行观察记录。进步率(%)=(治疗前分值-治疗后分值)/治疗前分值×100%。进步率>50%为显效,20%～49%为进步,<20%为稍好;总有效率(%)=显效例数+进步例数+稍好例数/总例数×100%。并分别于治疗前及治疗4个疗程后测定血浆和红细胞超氧化物歧化酶活性和过氧化脂质含量。结果:38例患者全部进入结果分析,无脱落。①4个疗程后总有效率:针药并用组显著高于药物对照组眼89.4%,52.6%(P=0.03)演。②统一帕金森病评定量表评分:针药并用组治疗2个疗程后统一帕金森病评定量表评分有所下降,但与治疗前比较差异无显著性意义(P>0.05);治疗4个疗程后评分显著低于治疗前及药物对照组(P<0.05)。③血浆及红细胞超氧化物歧化酶活性和过氧化脂质含量:治疗4个疗程后,针药并用组超氧化物歧化酶活性显著高于治疗前及药物对照组(P<0.05);针药并用组过氧化脂质含量显著低于治疗前及药物对照组(P<0.05)。结论:针刺可能通过提高帕金森患者血中超氧化物歧化酶活性和降低过氧化脂质的含量,提高机体的抗氧化能力,从而达到防治帕金森病的积极目的。
AIM： To investigate the interventional effect of acupuncture plus drug iu subjects with Parkinson disease, and the changes of activity of superoxide dismutase （SOD） and content of peroxidation lipid in plasma and akaryocytes.
METHODS： Totally 38 subjects with Parkinson disease, who hospitalized at Department of Acupuncture and Moxibustion, Acupuncture and Manipulation Hospital Affiliated to Zhejiang Chinese Medicine University from January 2004 to February 2006, were enrolled. They all participated the observation voluntarily, and assigned randomly into two groups： acupuncture plus drug group and drug control group with 19 cases. ①The subjects in the drug control group received benserazide-levodopa orally, 62.5-500 mg every time, 2--4 times per day. The treatment duration was the same to that in the acupuncture plus drug group. ②Acupuncture therapy was added in the acupuncture plus drug group, based on the drug given in the drug control group. The needles entered with scalp acupuncture horizontal method. Electric needle was turned on for 30 minutes after twisting for 3 minutes, Uniform reinforcing-reducing method was applied, retaining needles for 30 minutes, once every two days, 10 times as a course for 4 courses, resting for 7 days between two courses. Unified Parkinson＇s Disease Rating Scale （UPDRS） was used to evaluate clinical curative effect. The symptom was recorded before treatment, 2 or 4 courses after treatment, Progress rate （%） was equal to （score before treatment-score after treatment）/ score before treatment ×100%. Over 50% of progress rate represented significant effect; Between 20%- 49% represented advancement; Less than 20% represented slight effect. Total efficiency （%） was equal to number of persons with significant effect ＋ number of improved cases ＋ number of persons with slight effect/total cases ×100%. Activity of SOD and content of peroxidation lipid in plasma and akaryocytes were detected before treatment and after 4-course treatment, respectively.
RESULTS： A total of 38 subjects were involved in the result analysis, without dropout. ① Total efficiency after 4-course treatment： It was significantly higher in the acupuncture plus drug group than that in the drug control group [89.4% ,52.6% （P=0.03）], ②Score of UPDRS： It decreased in the acupuncture plus drug group after 2 courses, but there was insignificant difference as compared with that before treatment （P 〉 0.05 ）. The score was significantly lower than that before treatment and that in the drug control group after 4 courses （P 〈 0.05 ）. ③Activity of SOD and content of peroxidation lipid in plasma and akaryocytes： The activity of SOD was significantly higher in the acupuncture plus drug group than that before treatment and that in the drug control group after 4 courses （P 〈 0.05）. The content of peroxidation lipid in acupuncture plus drug group was significantly lower than that before treatment and that in thedrug control group （P 〈 0.05）.
CONCLUSION： Acupuncture can improve the ability of anti- oxidation to help prevent and control Parkinson disease by raising the activity of SOD and decreasing content of peroxidation lipid in subjects with Parkinson disease.
出处
《中国临床康复》
CSCD
北大核心
2006年第19期14-16,共3页
Chinese Journal of Clinical Rehabilitation
基金
上海市重点学科建设项目资助(T0302)~~
