摘要
AIM： TO investigate the correlation of depressed-type （0-IIc） colorectal neoplasm and family history of firstdegree relatives （FDR） with colorectal cancer （CRC）. METHODS： This cross-sectional study was conducted from June 2000 to October 2002 at National Cancer Center Hospital East. Eligible patients undergoing initial total colonoscopy were surveyed regarding family history of CRC among FDR by a questionnaire prior to colonoscopic examinations. All endoscopic findings during colonoscopy were recorded and the macroscopic classification of the early stage neoplasm/cancer was classified into two types （0-IIc vs non 0-IIc）. Odds ratios （OR） and 95% confidence intervals （CI） were calculated by univariate and multivariate logistic regression to estimate the association between macroscopic features and clinicopathological data including gender, age, and family history of FDR with CRC. RESULTS： The OR of an association between family history of FDR with CRC and overall early stage neoplasm adjusted by gender and age was 1.85 （95% CI： 1.31-2.61, P = 0.0004）, that for non 0-IIc neoplasm was 1.71 （95% CI： 1.22-2.41, P = 0.0017） and for 0-IIc colorectal neoplasm was 2.78 （95% CI： 1.49-5.16, P = 0.0031）. CONCLUSION： Our study shows a significant association between a family history of FDR with CRC and 0-IIc colorectal neoplasm. When patients with a family history of FDR with CRC undergo colonoscopy, colonoscopists should check carefully for not only polypoid, but also depressed-type （0-IIc） lesions.
瞄准：调查关联沮丧类型(0-IIc ) 与颜色渲染一度的亲戚(FDR ) 的表面的瘤和家庭历史表面的癌症(CRC ) 。方法：这代表性的研究在国家癌症中心医院东方从 2000 年 6 月被进行到 2002 年 10 月。经历起始的全部的结肠镜检查的合格病人被一张问询表在 colonoscopic 考试以前在 FDR 之中关于 CRC 的家庭历史调查。所有内视镜的调查结果在结肠镜检查期间被记录，早阶段瘤 / 癌症的宏观的分类被分类进二种类型(0-IIc 对非 0-IIc ) 。机会比率(或) 并且 95% 信心间隔(CI ) 被 univariate 并且多计算变量与 CRC 估计在 FDR 的宏观的特征和 clinicopathological 数据包括性，年龄，和家庭历史之间的协会的逻辑回归。结果：在有 CRC 和性和年龄调整的全面早阶段瘤的 FDR 的家庭历史之间的一个协会的 OR 是 1.85 (95% CI：1.31-2.61， P = 0.0004 ) ，那为非 0-IIc 瘤是 1.71 (95% CI：1.22-2.41， P = 0.0017 ) 并且为 0-IIc 颜色，表面的瘤是 2.78 (95% CI：1.49-5.16， P = 0.0031 ) 。结论：我们的学习证明在有 CRC 和 0-IIc 的 FDR 的家庭历史之间的一个重要协会渲染表面的瘤。当有有 CRC 的 FDR 的家庭历史的病人经历结肠镜检查时， colonoscopists 应该小心地检查不仅水虫息似，而且沮丧类型(0-IIc ) 损害。
