摘要
目的:探讨CD105在大肠癌中的表达及其作为肿瘤新生血管标记物的可能性及临床价值。方法:运用免疫组织化学技术检测CD105和CD34蛋白在80例大肠腺癌组织和40例正常肠组织中的表达情况,并计算微血管密度(m icrovessel density,MVD)。结果:大肠癌组织与正常肠组织间MVD的差异具有非常显著性意义(P<0.01);同组内以CD105和CD34测得MVD的差异也具有非常显著性意义(P<0.01)。结论:CD105在大肠癌组织新生血管中有良好表达,是新生血管的标志;以CD105测得的MVD是与肿瘤生长、转移及预后有关的一项重要指标。
Objective：To determine the expression of CD105 in colorectal cancer （CRC）, and to determine the probability and clinical value of CD105 as a marker of tumor - related angiogenesis. Methods：Immuno - histochemical technique was used to detect the expression of CD105 and CD34 protein in 80 cases of colorectal cancer and 40 cases of normal colorectal tissues,then to count the microvessel density （MVD）. Results ：The MVD in CRC tissues were significantly higher than those in normal colorectal tissues （P 〈0.01 ） ;the MVD marked by anti -CD105 in CRC and normal colorectal tissues was significantly higher than that marked by anti -CD34 （P 〈 0.01 ）. Conclusion： CD105 which is expressed highly in angiopoiesis of CRC is the marker of angiopoiesis; the MVD marked by anti -CD105 can be considered as an important index which is associated with tumor growth, metastasis and prognosis.
出处
《内蒙古医学院学报》
2006年第3期204-208,共5页
Acta Academiae Medicinae Neimongol
