摘要
模拟四氢叶酸辅酶转移一碳单元的反应,以苯并咪唑甲基碘盐作为甲酸氧化态的四氢叶酸辅酶模型,以G rignard试剂作为一碳单元的接受体,通过加成-水解反应为α-萘基环己基甲基酮提供了一种仿生合成新方法。产物α-萘基环己基甲基酮采用IR、MS1、H NMR测试技术进行了表征,通过反应机理及反应条件对收率的影响进行了讨论。
Based on the one-carbon unit transfer reaction of tetrahydrofolate coenzymes,α-naphthyl cyclohexyl ketone was synthesized successfully with benzoimidazolium salt as the tetrahydrofolate coenzyme model at formic acid oxidation level and Grignard reagent as a nucleophile to which one carbon unit was transferred via addition-hydrolysis reaction. This provides a new convenient biomimetic synthesis method to the title compound. The α-naphthyl cyclohexyl ketone was characterized by means of IR spectra, MS and ^1H NMR. The reaction mechanism and the effects of reaction conditions on the yield were investigated.
出处
《应用化学》
CAS
CSCD
北大核心
2006年第6期685-687,共3页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金(20472067)
高等学校博士学科点基金资助项目
