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HER2基因表达与骨肉瘤预后 被引量:3

Prognostic significance of HER2 expression in osteosarcoma
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摘要 目的:研究骨肉瘤中HER2基因的表达与临床预后的关系。方法:对82例骨肉瘤患者的临床病理资料进行回顾性研究,应用HER2单克隆抗体对组织切片进行免疫组织化学染色,并将上述资料与患者的预后进行分析。结果:骨肉瘤患者HER2表达与患者预后相关(P<0.05),HER2高表达的骨肉瘤患者预后较差。结论:HER2检测是骨肉瘤预后判断的一项有价值的指标;同时,HER2为骨肉瘤的治疗提供一种可能的生物靶点。 Objective:To evaluate the relationship between prognostic significance and the expression of HER2 in osteosarcoma. Methods: The clinicopathologic information of eighty - two patients with osteosarcoma was studied retrospectively. By using anti - HER2 monoclonal antibody, the expression of HER2 was assessed by standard immunohistochemical staining. The data together with the prognosis of patients were analyzed statistically. Results: The expression of HER2 was correlated with the patients'prognostic (P 〈 0.05 ). Conclusion: HER2 expression is one of the important prognostic factors in osteosarcoma. The correlation also suggests HER2 could be considered as a possible target for the gene therapy of osteosarcoma.
出处 《现代肿瘤医学》 CAS 2006年第6期742-744,共3页 Journal of Modern Oncology
基金 国家自然科学基金资助项目(No.30471988)
关键词 骨肉瘤 HER2 预后 免疫组织化学 osteosarcoma HER2 prognosis immunohistochemistry
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