摘要
目的探讨药物毒性角膜病变的发病机理及治疗。方法药物毒性角膜病变患者9例,停原滴眼液,局部滴用不含防腐剂的人工泪液,部分患者适量加用激素。结果4周后,单纯角膜浅表损伤2例,均治愈,平均治愈天数14d;合并角膜基质层损伤7例,治愈6例,有效1例,平均治愈天数28d;总治愈率88.89%(8/9)。随诊3月无复发,无树枝状角膜溃疡、前房积脓、霉菌感染等并发症出现。结论药物毒性角膜病变常发生在治疗原发病的过程中,长期过量局部使用含防腐剂的滴眼液会对角膜造成损害,而不含防腐剂的人工泪液和适量的激素有利于角膜上皮修复。
Objective To discuss the mechanism and therapy of drug toxic keratopathy. Methods Nine patients with drug toxic keratopathy were stopped the origin therapy manner, and used manmade tear fluid without preservative. Some patients were treated with excitatory autacoid. Results After 4 weeks, two patients with simple corneal epithelial injury were cured, and the mean cured time was 14 days; six patients were cured and one patient was effective in seven patients with corneal stroma injury, the mean cured time was 28 days; the total cure rate was 88. 89%. All patients were followed for 3 months, no recurrence and complications appeared. Conclusion Drug toxic keratopathy often appears in the process of treating original diseases; the longterm use of excessive eyedrops containing preservatives will be harm to the cornea;man-made tear fluid without preservatives and proper excitatory autacoid can be useful to repair the cornea epithelium.
出处
《眼科新进展》
CAS
2006年第6期456-457,共2页
Recent Advances in Ophthalmology
关键词
药物
毒性
防腐剂
角膜病变
drug
toxicity
preservative
keratopathy
