摘要
目的:探讨CXCL12—CXCR4在肿瘤转移中的作用。方法:查阅国内外相关文献,进行综述。结果:研究表明许多肿瘤细胞表达趋化因子CXCL12和受体CXCR4,与肿瘤细胞的迁移与转移有密切关系。CXCL12—CXCR4生物学轴在多种肿瘤的播散和器官特异性转移中发挥着重要的作用,对一特殊生物学轴的研究可能为肿瘤转移找到新的突破口。结论:趋化因子CXCL12、受体CXCR4和CXCL12—CXCR4生物学轴在肿瘤转移中发挥着重要的作用。
Objective： To explore the effect os CXCL12 - CXCR4 on tumor metastasis. Methods：Looking up domestic and foreign literatures and reviewing them. Results： Researchs indicated that various tumor cells expressed chemotactic factor CXCL12 and its receptor CXCR4, which was closely related to migration and metastasis of tumor ceils. The biological axis of CXCL12 - CXCR4 played important roles in migration and metastasis to specific organs in various tumors. Reseach on the special biological axis provided a new approach to tumor matastasis. Conclusion ：The chemokine factor CXCL12, its receptor CXCR4 and biological axis of CXCL12 - CXCR4 play important roles in tumor metastasis.
出处
《内蒙古医学杂志》
2006年第1期61-63,共3页
Inner Mongolia Medical Journal
