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胰岛素抵抗和非酒精性脂肪性肝病研究进展 被引量:20

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摘要 非酒精性脂肪性肝病(NAFLD)是现在临床上最为常见的肝病之一,其病因及发病机制均相当复杂,至今尚未完全阐明.目前认为,胰岛素抵抗(IR)不仅是NAFLD的触发因素,而且还可能间接促进单纯性脂肪肝向脂肪性肝炎(NASH)乃至肝纤维化转变的过程.至于IR是否直接参与NASH的发生、发展尚存在争议.此外,NAFLD本身也可能诱发及加重IR,比如肝细胞内蓄积的脂肪、TNF-α、瘦素抵抗等都参与这一过程.随着二者关系及相关因素的发展,NAFLD在诊疗方面也取得了较大的进展.近年来,有关这方面的研究很多,本文对此作阐述.
出处 《世界华人消化杂志》 CAS 北大核心 2006年第12期1197-1202,共6页 World Chinese Journal of Digestology
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