摘要
The rats were fed with water dissolved Y^3＋ at different levels （0, 53.4, 5340 mg·L^-1） for 7 months. The gene expression in brain tissue was detected with oligonucleotide microarray. The results show that, compared to the control, 789 genes express differentially, 507 over-expressed genes and 282 under-expressed genes in the high-dose group （5340 mg· L^-1）, of which, most were related to cell receptor, cell signal and transmission, and ionic passage. 44 genes were found to express differentially including 32 over-expressed genes and 12 under-expressed genes in the low-dose group （53. 40 mg· L^-1）, of which, most were related to cell skeleton and movement, immunity, and DNA binding protein. These resuits suggest that Y^3. can change the expression of some genes, which may be responsible for the toxicity of rare earths on learning and memory.
The rats were fed with water dissolved Y^3＋ at different levels （0, 53.4, 5340 mg·L^-1） for 7 months. The gene expression in brain tissue was detected with oligonucleotide microarray. The results show that, compared to the control, 789 genes express differentially, 507 over-expressed genes and 282 under-expressed genes in the high-dose group （5340 mg· L^-1）, of which, most were related to cell receptor, cell signal and transmission, and ionic passage. 44 genes were found to express differentially including 32 over-expressed genes and 12 under-expressed genes in the low-dose group （53. 40 mg· L^-1）, of which, most were related to cell skeleton and movement, immunity, and DNA binding protein. These resuits suggest that Y^3. can change the expression of some genes, which may be responsible for the toxicity of rare earths on learning and memory.
基金
ProjectsupportedbyFoundationofScienceandTechnologyResearchofGuangzhouCity(2003J1C0041)
