摘要
研究异氟醚控制性降压时可乐定对异氟醚挥发浓度及血浆儿茶酚胺水平的影响。24例ASA Ⅰ～Ⅱ级,颅脑择期手术患者随机分为两组。Ⅰ组为单纯异氟醚降压组(n=12);Ⅱ组为可乐定加异氟醚降压组(n=12)。两组患者平均动脉压较降压前降低25%。结果提示:可乐定能显著降低异氟醚降压诱导和维持时的吸入、潮气末浓度;不影响降压期间血浆儿茶酚胺水平。
The effects of clonidine as a premedicant were studied during isoflurane-indueed hypotension(IIH). Twenty-four adult patient, ASA grade Ⅰ-Ⅱ, scheduled for elective cerebral surgery, were randomly allocated into two groups. Atropine 0.5mg and luminal sodium 100mg were given I. M. as premedication in group Ⅰ 30 mins before induction, and clonidine 5μg·kg^(-1)P. O. was combined in group Ⅱ 90 mins prior to induction. The methods of both groups were similar in induction and maintenance of anesthesia. The status of hypotension was induced and kept by inhaltion of isoflurane, with MAP being decreased by 25% or so. The arterial plasma Concentrations of adrenaline and noradrenaline were measured by electrochemistry method, at preoperation, prior to hypotension, 15 and 30 mins following IIH and 30 mins after MAP recovery, respectively. The results revealed that as compared with the values in group Ⅰ, the inspired and end-tidal concentrations of isoflurane reduced significantly during induction and maintenance of controlled hypotension (P<0.05). The airway pressure and plasma levels of adrenaline and noradrenaline kept statistically unchanged during whole observation in either group (P>0.05). It is suggested that clonidine premedication can increase the efficiency of isoflurane for controlled hypotension and do not affect the plasma catecholamine concentration and airway function.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1996年第3期99-101,共3页
Chinese Journal of Anesthesiology
关键词
可乐定
异氟醚
控制性降压
降压
儿茶酚
胺
Clonidine Isoflurane Controlled hypotension Cateeholamine Airway pressure
