摘要
目的探讨穴位注射法治疗HBsAg携带者的临床疗效。方法对83例病人随机分为治疗组48例,予穴位注射苦参素及复方丹参注射液;对照组35例予一般护肝治疗。结果治疗组1个疗程后HBVDNA阴转率为27.08%,与对照组相比有显著性差异(P<0.05)。治疗2个疗程后治疗组HBVDNA阴转率为41·67%,HBeAg转阴率为20·83%。对照组HBVDNA、HBeAg转阴率分别为11·43%、14·29%,两组比较HBVDNA、HBeAg均有显著性差异(P<0·05)。治疗3个疗程后治疗组HBVDNA、HBeAg阴转率分别为58·33%、47·91%,对照组HBVDNA、HBeAg阴转率分别为22·86%、20·00%,两组比较HBVDNA、HBeAg均有显著性差异(P<0·05)。而在整个治疗过程中治疗组与对照组相比HBsAg阴转率无明显差异性。治疗前后两组肝纤三项指标均有变化,但对照组经统计学处理无显著性差异,治疗组在每个疗程结束后肝纤三项指标均有变化,与对照组相比均有显著性差异(P<0·05)。治疗组15例患者在三个疗程结束后肝细胞病理学提示炎症程度改善率为40%,纤维化程度改善率为26·67%。结论穴位注射苦参素及复方丹参注射液能够提高HBsAg携带者的HBeAg、HBV-DNA的阴转率,减轻肝细胞的炎症及纤维化。
Objective To study the clinical effect of point injection in the treatment of chronic HBsAg carrier. Methods 83 patients were randomly divided into the treatment group and control group, and study the serum marks＇ changes at the end of treatment. The treatment group consisted of 48 patients treated with point injection of oxymatrine and salvia miltlorrhiza compound injection, while the control group consisted of 35 patients treated with glucurolactone, vitamins Bco and C. Results After one course of treatment , bepatitist B virus （HBV） DNA became negative （ P 〈0.05） in significantly higer proportion of control group （5.78%）. At end of two courses of treatment, three courses of treatment, HBeAg and HBVDNA were in 20.83%, 41.67% and 47.91%, 58.33% of treatment group and in 14.29%, 11.43% and 20.00%, 22.86% of control group, respectively （ P 〈0.05 ）. In all three courses of treatment, the negative of HBeAg had insignificant difference between the treatment group and the control group. The fibrosis marks had changes in treatment group and control group after treatment. Aslo changes of fibrosis marks were significant different after each course of treatment in the treatment group, but changes of fibrosis were insignificant different in the control group. After three courses of treatment , liver pathology of 15 patients in treatment group indicated that necrosis- inflammation grade and fibrosis stage improved by 40% and 26.67% .Conclusions Point injection of oxymatrine and salvia miltiorrhiza compound injection can increase the negative of HBeAg, HBV - DNA in the patients with chronic hepatitist B and decrease hepatic necrosis- inflammation and fibrosis.
基金
廉江市科技局基金课题编号020005
关键词
穴位注射法
慢性乙型肝炎
苦参素
复方丹参注射液
point injection
chronic hepatitist B
oxymatrine
salvia miltiorrhiza compound injection
