摘要
目的:观察三维适形放疗(3D-CRT)配合化疗治疗期非小细胞肺癌(NSCLC)的近期疗效与急性毒副反应。方法:30例期非小细胞肺癌患者进入三维适形放疗加化疗组,肺鳞腺癌行NP方案化疗加3D-CRT治疗。结果:30例全部完成治疗计划,原发灶完全缓解(CR)占23.3%,部分缓解(PR)占70%,无变化和进展(NR+PD)占6.66%,总有效率为93.3%,纵隔转移淋巴结,完全缓解(CR)占43.3%,部分缓解(PR)占56.6%,无变化和进展(NR+PD)为0%,总有效率为100%。白细胞下降发生率为93.3%,其中、度白细胞下降为56.6%;放射性食管炎和放射性肺炎的发生率为53.3%和10%,均为、级。结论∶三维适形放疗配合化疗治疗晚期(期)非小细胞肺癌能为多数患者耐受,有较好的近期疗效。
Objective：To observe the effects and acute side effects in the treatment of stage Ⅲ non-small cell lung cancer （NSCLC） by three dimensional-conformal radiotherapy （3D-CRT） combined with chemotherapy （CT）. Methods： Thirty cases with stage Ⅲ of NSCLC were treated by 3D-CRT combined with CT. Those with squamous cell carcinoma of lung were treated by 3D-CRT plus NP. Results： All 30 cases had undergone treatment schedules. The rate of complete remission （CR） for primary tumor was 23.3%, the partial remission （PR） accounted for 70%, no remission and no advance was found in 6.66%. Total effective rate was 93. 3%. The complete remission for metastatic mediastinal lymph nodes reached 43. 3%, partial remission 56.6%, no remission and no advance 0%. Total effective rate was 100%. WBC decrease incidence was 93. 3%, of which white blood cells at Degrees Ⅲ and Ⅳ decreased by 56.6%. The incidence rates of radioactive esophagitis and pneumonia were 53. 3% and 10%, respectively （averaging Degree Ⅰ and Ⅱ ）. Conclusion：Three dimensional-conformal radiotherapy combined with chemotherapy in the treatment of stage Ⅲ of NSCLC could be well tolerated by most cases and has good short-term efficacy.
出处
《陕西医学杂志》
CAS
北大核心
2006年第6期703-705,共3页
Shaanxi Medical Journal
关键词
癌
小细胞/放射疗法
药物疗法
Carcinoma, small cell/Radiotherapy Chemotherapy
