摘要
研究高血压病人的钠负荷时肾脏多巴胺（ＤＡ）生成量的变化。方法７例年龄５６～６５岁的高血压病患者（Ａ组）、７例年龄匹配的正常人（Ｂ组）以及１０例年青健康自愿者（Ｃ组）在代谢平衡状态下将摄钠量从３４ｍｍｏｌ／ｄ增至１７０ｍｍｏｌ／ｄ。观察各组血尿ＤＡ、Ｃｃｒ等变化。结果Ｂ组和Ｃ组增加钠负荷后尿ＤＡ均明显增加，但Ｂ组尿ＤＡ的增幅小于Ｃ组。与此相反，高血压病患者钠负荷后尿ＤＡ最初降低，而后逐渐升至基础值。各组尿钠的变化与尿ＤＡ平衡。三组血浆ＤＡ、Ｃｃｒ和平均动脉压均无变化，但Ａ组钠负荷后血钠增高，血细胞压积降低，体重增加量大于对照组。结论肾脏ＤＡ生成能力与年龄有关。高血压病患者在增加钠负荷时，肾脏不能相应增加ＤＡ的生成。
bjectiveTostudyrenalmobilizationofdopamine(DA)inresponsetosodiumloadinginpatientswithes-sentialhypertension.MethodsSevenpatientsagedbetween56～65years(GroupA),7age-matchednormalcon-trols(GroupB)and10healthyyoungvolunteers(GroupC)wereenroledinthisstudyundermetabolicbalanceconditionsovera8daysperiodduringwhichdietarysodiumintakewasincreasedfrom34mmol/dayto170mmol/day.PlasmaDA,urinaryDA,Ccrwereobserved.ResultsNormalsubjects(BandC)showedapromptriseinurineDAoutputwhengivensodiumloading,butthemagnitudeofDAincreaseinGroupBwaslessthanthatob-tainedinGroupC.IncontrasttheurineDAexcretioninpatientswithessentialhypertensionshowedaninitialfalfolowedbyareturntobaselinevalues.ThechangesinurinesodiumoutputinthethreegroupswereparaleltourineDAexcretion.NeithergroupshowedachangeinplasmaDA、Ccr、andbloodpressure,butthepatientsofGroupAshowedariseinplasmasodium,adecreaseinhematocritandagreaterweightgainaftersodiumloading.Theplasmareninactivityandaldosteronewerelesssuppressedinhypertensivegroup,althoughthedifferencewasnotstatisticalysignificant.ConclusionRenalmobilizationofDAmayberelatedtoage.Thepatientswithessen-tialhypertensionhaveafaultinrenalDAmobilizationwhengivensodiumloading.Thisdefectmaybeimportantinrelationtorenalsodiumhandlingbypatientswithessentialhypertension.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1996年第4期195-198,共4页
Chinese Journal of Nephrology
