摘要
了解中药汉防己甲素(Tet)和维拉帕米(Ver)对环孢素A肾毒性(CsA-NT)的防护作用。方法一组大鼠用CsA50mg·kg-1/d灌胃7天导致急性CsA中毒,另二组在给CsA前,分别给Ver及Tet。结果CsA中毒大鼠表现为血清肌酐升高34.8%,Ccr下降39.4%,并出现近曲小管大片空泡变性。同时,肾皮质丙二醛(MDA)含量显著升高,超氧化物歧化酶(SOD)活性显著下降。给予Tet或Ver均能使上述肾功能和脂质过氧化指标明显改善,Tet还能减轻CsA所致的组织学损害。
bjectiveToinvestigatetheeffectoftetrandrine(Tet),aChinesemedicinalherb,andverapamil(Ver)oncyclosporineAnephrotoxicity(CsA-NT)intherats.MethodsAdministeringCsA50mg·kg-1/dtoonegroupofratsbygavagefor7daysresultedinacuteCsApoisoning,othertwogroupsreceivedTetandVerbeforeCsA.Re┐sultsRatswithCsA-NThada34.8%increaseinserumcreatinineanda39.4%decreaseinCcr.Histologicalex-aminationdemonstratedanextensivevacuolizationinproximaltubule.Inaddition,renalcorticalmalondialdehyde(MDA)increasedsignificantly,buttheactivitiesofrenalcorticalsuperoxidedismutase(SOD)decreasedsignifi-cantly.Inprotectiveexperiment,valuesoftheparametersmentionedaboveweresignificantlyimprovedinTetandVergroup,andthehistologicaldamagewassignificantlyreducedinTetgroups.ConclusionTetcanprotectkid-neyfromCsA-NT.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1996年第4期217-220,共4页
Chinese Journal of Nephrology