摘要
了解经常给低蛋白血症的肾病综合征病人输注人体白蛋白是否合理。方法２９例微小病变肾病综合征，１１例输注人体白蛋白（甲组），１８例未输注（乙组）。两组患者入院时血浆总蛋白、白蛋白、尿蛋白量、肾功能、肾活检病理类型无差别（Ｐ＞０．０５），强的松治疗方案相同，故两组有可比性。结果甲组达到完全缓解需８３．４±４５．４天，乙组仅２２．１±１３．８天（Ｐ＜０．０１）；而且，输注白蛋白量越多，达到缓解所需天数越长（ｒ＝０．６５，Ｐ＜０．０１）。结论静脉输注人体白蛋白对微小病变肾病综合征起不利作用。
bjectiveIsitreasonableornotthathumanalbumininfusionisfrequentlyadministeredtohypoalbuminemianephroticsyndrome(NS)patients.Methods29caseswithminimalchangenephroticsyndrome(MCNS)inwhich11casesweretreatedwithhumanalbumin(groupA)and18caseswerenot(groupB).Therewerenoanysignifi-cantdiferencesbetweengroupAandgroupBintotalserumprotein,albumin,urineproteinexcretion,renalfunc-tionandrenalbiopsymorphologicabnormalities.Thetreatmentprogramofprednisonewasalsoequivalentinbothgroups.Therefore,groupAandgroupBwerecomparable.ResultsTheperiodrequiredfromthestartofpred-nisonetherapytocompleteremissionofgroupAwassignificantlylongerthanthatofgroupB(83.4±45.4vs22.1±13.8days,P<0.01).Moreover,significantcorelationwasobservedbetweentheperiodrequiredforremissionandthetotalvolumeofalbumininfusion(r=0.65,P<0.01).ConclusionHumanalbumininfusionplaysadisad-vantageefectinMCNS.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1996年第3期144-146,共3页
Chinese Journal of Nephrology
